β-eudesmol inhibits thymic stromal lymphopoietin through blockade of caspase-1/NF-κB signal cascade in allergic rhinitis murine model

Phil Dong Moon, Na Ra Han, Jin Soo Lee, Hee Yun Kim, Sungwei Hong, Hyeong Jin Kim, Min Sun Yoo, Hyung Min Kim, Hyun Ja Jeong

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Allergic rhinitis (AR) is a global health problem because of its steadily increasing incidence and prevalence that currently affects about 30% of people worldwide. β-eudesmol has various beneficial effects, including anti-cancer and anti-allergic activities. However, the effects of β-eudesmol on AR have not yet been clarified; thus, we investigated the effects of β-eudesmol in an ovalbumin-induced AR animal model using enzyme-linked immunosorbent assay, histamine assay, Western blotting, and hematoxylin and eosin staining methods. β-eudesmol reduced the nasal rubs score and levels of histamine and immunoglobulin E in serum of AR mouse. In addition, the levels of thymic stromal lymphopoietin, interleukin-1β tumor necrosis factor-α and macrophage inflammatory protein-2 were down-regulated and infiltration of eosinophils and the level of intercellular adhesion molecule-1 were inhibited by β-eudesmol administration. β-eudesmol administration also reduced active caspase-1 and nuclear factor-κB DNA binding activity in nasal mucosa tissues of AR mice. Taken together, these results indicate that β-eudesmol would be effective for the treatment of allergic and inflammatory diseases, such as AR.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalChemico-Biological Interactions
Volume294
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • Allergic rhinitis
  • Caspase-1
  • Nuclear factor-κB
  • Thymic stromal lymphopoietin
  • β-eudesmol

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