Abstract
4-1BB, a T cell co-stimulatory receptor, prolongs the survival and multiplication of CD4 T cells. Cross-linking 4-1BB stimulated expression of the anti-apoptotic genes bcl-XL and bcl-2, as well as of cyclins D2 and E, and inhibited expression of the cyclin-dependent kinase (cdk) inhibitor p27kip1. Ova-activated CD4 T cells of 4-1BB-deficient/DO11.10 TCR transgenic mice survived less well and underwent less expansion than cells of wild type DO11.10 TCR transgenic mice. These findings demonstrate that 4-1BB is a co-stimulatory molecule for CD4 T cell survival and expansion in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 143-150 |
| Number of pages | 8 |
| Journal | Cellular Immunology |
| Volume | 223 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2003 |
Bibliographical note
Funding Information:This work was supported by a grant from the SRC Fund to IRC at University of Ulsan from the KOSEF and the Ministry of Science and Technology, Korea.
Keywords
- 4-1BB
- CD4 T cells
- Cell cycle
- Cyclins
- DO11.10 TCR transgenic mice
- Survival
- bcl-2
- bcl-X
- p27
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