4-(2-Hydroxyethyl)-1-piperazine ethane sulfonic acid repositioning: Amyloid disaggregating agent and its sustained-release system

Jaehoon Kim, Dokyoung Kim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Here, we report the results of experiments regarding the chemical repositioning of 4-(2-hydroxyethyl)-1-piperazine ethane sulfonic acid (HEPES), a representative buffering agent. In this work, we confirmed that HEPES could disaggregate amyloid plaques, a hallmark of Alzheimer's disease, and we verified its sustained-release system (release for up to 2 weeks) via hybridization with a biocompatible polymer (Eudragit S100).

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalBulletin of the Korean Chemical Society
Volume43
Issue number1
DOIs
Publication statusPublished - Jan 2022

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