4-(2-Hydroxyethyl)-1-piperazine ethane sulfonic acid repositioning: Amyloid disaggregating agent and its sustained-release system

Jaehoon Kim; Dokyoung Kim

doi:10.1002/bkcs.12433

4-(2-Hydroxyethyl)-1-piperazine ethane sulfonic acid repositioning: Amyloid disaggregating agent and its sustained-release system

Jaehoon Kim, Dokyoung Kim

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Here, we report the results of experiments regarding the chemical repositioning of 4-(2-hydroxyethyl)-1-piperazine ethane sulfonic acid (HEPES), a representative buffering agent. In this work, we confirmed that HEPES could disaggregate amyloid plaques, a hallmark of Alzheimer's disease, and we verified its sustained-release system (release for up to 2 weeks) via hybridization with a biocompatible polymer (Eudragit S100).

Original language	English
Pages (from-to)	78-82
Number of pages	5
Journal	Bulletin of the Korean Chemical Society
Volume	43
Issue number	1
DOIs	https://doi.org/10.1002/bkcs.12433
Publication status	Published - Jan 2022

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10.1002/bkcs.12433

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abstract = "Here, we report the results of experiments regarding the chemical repositioning of 4-(2-hydroxyethyl)-1-piperazine ethane sulfonic acid (HEPES), a representative buffering agent. In this work, we confirmed that HEPES could disaggregate amyloid plaques, a hallmark of Alzheimer's disease, and we verified its sustained-release system (release for up to 2 weeks) via hybridization with a biocompatible polymer (Eudragit S100).",

author = "Jaehoon Kim and Dokyoung Kim",

note = "Funding Information: This research was supported by a grant from Kyung Hee University in 2020 (KHU‐20201211). Funding Information: This research was supported by a grant from Kyung Hee University in 2020 (KHU-20201211). Publisher Copyright: {\textcopyright} 2021 Korean Chemical Society, Seoul & Wiley-VCH GmbH",

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AU - Kim, Dokyoung

N1 - Funding Information: This research was supported by a grant from Kyung Hee University in 2020 (KHU‐20201211). Funding Information: This research was supported by a grant from Kyung Hee University in 2020 (KHU-20201211). Publisher Copyright: © 2021 Korean Chemical Society, Seoul & Wiley-VCH GmbH

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AB - Here, we report the results of experiments regarding the chemical repositioning of 4-(2-hydroxyethyl)-1-piperazine ethane sulfonic acid (HEPES), a representative buffering agent. In this work, we confirmed that HEPES could disaggregate amyloid plaques, a hallmark of Alzheimer's disease, and we verified its sustained-release system (release for up to 2 weeks) via hybridization with a biocompatible polymer (Eudragit S100).

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4-(2-Hydroxyethyl)-1-piperazine ethane sulfonic acid repositioning: Amyloid disaggregating agent and its sustained-release system

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