A compact SPECT/CT system for small animal imaging

Key Jo Hong; Yong Choi; Sang Chul Lee; Soo Yeol Lee; Tae Yong Song; Byung Jun Min; Jin Ho Jung; Yearn Seong Choe; Kyung Han Lee; Byung Tae Kim

doi:10.1109/TNS.2006.880972

A compact SPECT/CT system for small animal imaging

Key Jo Hong
, Yong Choi
, Sang Chul Lee
, Soo Yeol Lee
, Tae Yong Song
, Byung Jun Min
, Jin Ho Jung
, Yearn Seong Choe
, Kyung Han Lee
, Byung Tae Kim

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A dual-modality compact SPECT/CT system for small animal imaging was developed. The SPECT system consisted of a pinhole collimator and continuous NaI(Tl) scintillation crystal coupled to a PSPMT. The CT system consisted of a microfocus X-ray tube and a CMOS flat-panel detector. The SPECT system was mounted perpendicular to the X-ray system. Individual projections of the SPECT and the CT were acquired by rotating the animal on a vertical axis in front of the detectors. The SPECT and CT images were reconstructed using OSEM and Feldkamp's cone-beam algorithms, respectively. Mouse and rat SPECT images demonstrated detailed activity distribution at the expected structures. A CT image obtained with 40 kVp and 0.5 mA presented high-resolution anatomic details. Fused SPECT/CT images demonstrated good agreement between the CT images and the corresponding uptake of the radiotracer. The SPECT/CT system developed in this study provides high-quality dual-modality images and could be useful to obtain functional images with high resolution morphology information.

Original language	English
Article number	1710244
Pages (from-to)	2601-2604
Number of pages	4
Journal	IEEE Transactions on Nuclear Science
Volume	53
Issue number	5
DOIs	https://doi.org/10.1109/TNS.2006.880972
Publication status	Published - Oct 2006

Bibliographical note

Funding Information:
Manuscript received January 23, 2006; revised May 4, 2006. This work was supported in part by the Korea Science and Engineering Foundation (KOSEF), the Ministry of Science and Technology (MOST) through their National Nuclear Technology Program, and by a Grant of the Korea Health 21 R&D Project (02-PJ3-PG6-EV06-0002), Ministry of Health and Welfare, Republic of Korea.

Keywords

Multimodality imaging
Single photon emission computed tomography
Small animal imaging
X-ray imaging

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10.1109/TNS.2006.880972

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title = "A compact SPECT/CT system for small animal imaging",

abstract = "A dual-modality compact SPECT/CT system for small animal imaging was developed. The SPECT system consisted of a pinhole collimator and continuous NaI(Tl) scintillation crystal coupled to a PSPMT. The CT system consisted of a microfocus X-ray tube and a CMOS flat-panel detector. The SPECT system was mounted perpendicular to the X-ray system. Individual projections of the SPECT and the CT were acquired by rotating the animal on a vertical axis in front of the detectors. The SPECT and CT images were reconstructed using OSEM and Feldkamp's cone-beam algorithms, respectively. Mouse and rat SPECT images demonstrated detailed activity distribution at the expected structures. A CT image obtained with 40 kVp and 0.5 mA presented high-resolution anatomic details. Fused SPECT/CT images demonstrated good agreement between the CT images and the corresponding uptake of the radiotracer. The SPECT/CT system developed in this study provides high-quality dual-modality images and could be useful to obtain functional images with high resolution morphology information.",

keywords = "Multimodality imaging, Single photon emission computed tomography, Small animal imaging, X-ray imaging",

author = "Hong, \{Key Jo\} and Yong Choi and Lee, \{Sang Chul\} and Lee, \{Soo Yeol\} and Song, \{Tae Yong\} and Min, \{Byung Jun\} and Jung, \{Jin Ho\} and Choe, \{Yearn Seong\} and Lee, \{Kyung Han\} and Kim, \{Byung Tae\}",

note = "Funding Information: Manuscript received January 23, 2006; revised May 4, 2006. This work was supported in part by the Korea Science and Engineering Foundation (KOSEF), the Ministry of Science and Technology (MOST) through their National Nuclear Technology Program, and by a Grant of the Korea Health 21 R\&D Project (02-PJ3-PG6-EV06-0002), Ministry of Health and Welfare, Republic of Korea.",

year = "2006",

month = oct,

doi = "10.1109/TNS.2006.880972",

language = "English",

volume = "53",

pages = "2601--2604",

journal = "IEEE Transactions on Nuclear Science",

issn = "0018-9499",

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AU - Hong, Key Jo

AU - Choi, Yong

AU - Lee, Sang Chul

AU - Lee, Soo Yeol

AU - Song, Tae Yong

AU - Min, Byung Jun

AU - Jung, Jin Ho

AU - Choe, Yearn Seong

AU - Lee, Kyung Han

AU - Kim, Byung Tae

N1 - Funding Information: Manuscript received January 23, 2006; revised May 4, 2006. This work was supported in part by the Korea Science and Engineering Foundation (KOSEF), the Ministry of Science and Technology (MOST) through their National Nuclear Technology Program, and by a Grant of the Korea Health 21 R&D Project (02-PJ3-PG6-EV06-0002), Ministry of Health and Welfare, Republic of Korea.

PY - 2006/10

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N2 - A dual-modality compact SPECT/CT system for small animal imaging was developed. The SPECT system consisted of a pinhole collimator and continuous NaI(Tl) scintillation crystal coupled to a PSPMT. The CT system consisted of a microfocus X-ray tube and a CMOS flat-panel detector. The SPECT system was mounted perpendicular to the X-ray system. Individual projections of the SPECT and the CT were acquired by rotating the animal on a vertical axis in front of the detectors. The SPECT and CT images were reconstructed using OSEM and Feldkamp's cone-beam algorithms, respectively. Mouse and rat SPECT images demonstrated detailed activity distribution at the expected structures. A CT image obtained with 40 kVp and 0.5 mA presented high-resolution anatomic details. Fused SPECT/CT images demonstrated good agreement between the CT images and the corresponding uptake of the radiotracer. The SPECT/CT system developed in this study provides high-quality dual-modality images and could be useful to obtain functional images with high resolution morphology information.

AB - A dual-modality compact SPECT/CT system for small animal imaging was developed. The SPECT system consisted of a pinhole collimator and continuous NaI(Tl) scintillation crystal coupled to a PSPMT. The CT system consisted of a microfocus X-ray tube and a CMOS flat-panel detector. The SPECT system was mounted perpendicular to the X-ray system. Individual projections of the SPECT and the CT were acquired by rotating the animal on a vertical axis in front of the detectors. The SPECT and CT images were reconstructed using OSEM and Feldkamp's cone-beam algorithms, respectively. Mouse and rat SPECT images demonstrated detailed activity distribution at the expected structures. A CT image obtained with 40 kVp and 0.5 mA presented high-resolution anatomic details. Fused SPECT/CT images demonstrated good agreement between the CT images and the corresponding uptake of the radiotracer. The SPECT/CT system developed in this study provides high-quality dual-modality images and could be useful to obtain functional images with high resolution morphology information.

KW - Multimodality imaging

KW - Single photon emission computed tomography

KW - Small animal imaging

KW - X-ray imaging

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M3 - Article

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JF - IEEE Transactions on Nuclear Science

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ER -

A compact SPECT/CT system for small animal imaging

Abstract

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Keywords

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