A concise synthesis of tetrabenazine: An intramolecular aza-prins-type cyclization via oxidative c-h activation

Young Wook Son; Tae Hui Kwon; Jae Kyun Lee; Ae Nim Pae; Jae Yeol Lee; Yong Seo Cho; Sun Joon Min

doi:10.1021/ol202792q

A concise synthesis of tetrabenazine: An intramolecular aza-prins-type cyclization via oxidative c-h activation

Young Wook Son, Tae Hui Kwon, Jae Kyun Lee, Ae Nim Pae, Jae Yeol Lee, Yong Seo Cho, Sun Joon Min

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

A concise synthesis of tetrabenazine and dihydrotetrabenazine is described. The key feature of this synthesis is the intramolecular aza-Prins-type cyclization of an amino allylsilane via oxidative C-H activation.

Original language	English
Pages (from-to)	6500-6503
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	24
DOIs	https://doi.org/10.1021/ol202792q
Publication status	Published - 16 Dec 2011

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title = "A concise synthesis of tetrabenazine: An intramolecular aza-prins-type cyclization via oxidative c-h activation",

abstract = "A concise synthesis of tetrabenazine and dihydrotetrabenazine is described. The key feature of this synthesis is the intramolecular aza-Prins-type cyclization of an amino allylsilane via oxidative C-H activation.",

author = "Son, {Young Wook} and Kwon, {Tae Hui} and Lee, {Jae Kyun} and Pae, {Ae Nim} and Lee, {Jae Yeol} and Cho, {Yong Seo} and Min, {Sun Joon}",

year = "2011",

month = dec,

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language = "English",

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journal = "Organic Letters",

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T1 - A concise synthesis of tetrabenazine

T2 - An intramolecular aza-prins-type cyclization via oxidative c-h activation

AU - Son, Young Wook

AU - Kwon, Tae Hui

AU - Lee, Jae Kyun

AU - Pae, Ae Nim

AU - Lee, Jae Yeol

AU - Cho, Yong Seo

AU - Min, Sun Joon

PY - 2011/12/16

Y1 - 2011/12/16

N2 - A concise synthesis of tetrabenazine and dihydrotetrabenazine is described. The key feature of this synthesis is the intramolecular aza-Prins-type cyclization of an amino allylsilane via oxidative C-H activation.

AB - A concise synthesis of tetrabenazine and dihydrotetrabenazine is described. The key feature of this synthesis is the intramolecular aza-Prins-type cyclization of an amino allylsilane via oxidative C-H activation.

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U2 - 10.1021/ol202792q

DO - 10.1021/ol202792q

M3 - Article

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SN - 1523-7060

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SP - 6500

EP - 6503

JO - Organic Letters

JF - Organic Letters

IS - 24

ER -

A concise synthesis of tetrabenazine: An intramolecular aza-prins-type cyclization via oxidative c-h activation

Abstract

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