A fluorescent nanoprobe based on AIEgen: Visualization of silver ions and sensing applications in cancer cells and S. aureus

Na Hee Kim, Rae Hyung Kang, Peter Verwilst, Dokyoung Kim

Research output: Contribution to journalArticlepeer-review

Abstract

We have developed a fluorescent nanoprobe (AgP-1) that can detect silver ions (Ag+) in biological media. For the first time, a hybridized structure based on AIEgen (tetraphenylethylene; TPE) and 2-(methylthio)aniline (MTA) moiety has been designed, and its unique sensing properties toward silver ions were systematically analyzed. The nanoprobe AgP-1 has an aggregated form with weak fluorescence and showed significant fluorescence enhancement (3.7-fold) upon forming complex with silver ions. AgP-1 has high selectivity, high sensitivity (detection limit 6.6 ppb), a fast response time (fluorescence enhancement within 10 s), and superior biocompatibility. Visualization of silver ions in cancer cells (U87 glioblastoma) and bacteria (S. aureus) was also successfully demonstrated. We believe AgP-1 holds a great potential to serve as a practical sensor for silver ions detection in biomedical applications.

Original languageEnglish
Article number110027
JournalDyes and Pigments
Volume198
DOIs
Publication statusPublished - Feb 2022

Keywords

  • 2-(methylthio)aniline moiety
  • Aggregation-induced emission
  • Fluorescent imaging
  • Fluorescent probe
  • Silver ion

Fingerprint

Dive into the research topics of 'A fluorescent nanoprobe based on AIEgen: Visualization of silver ions and sensing applications in cancer cells and S. aureus'. Together they form a unique fingerprint.

Cite this