A mm-sized implantable glucose sensor using a fluorescent hydrogel

Hyeonkeon Lee; Honghyeon Park; Taein Kim; Mi Song Nam; Yun Jung Heo; Sanghoek Kim

doi:10.1109/RFIC54547.2023.10186146

A mm-sized implantable glucose sensor using a fluorescent hydrogel

Hyeonkeon Lee
, Honghyeon Park
, Taein Kim
, Mi Song Nam
, Yun Jung Heo
, Sanghoek Kim

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

This work proposes a millimeter-sized implantable glucose sensor using a fluorescent hydrogel based on boronic acids. The readout system is configured to provide an efficient wireless power transfer to the implantable sensor at 920-MHz frequency. The 675×959-μm2 die fabricated in 180-nm CMOS consists of a rectifier, a bandgap reference, two regulators, a trans-impedance amplifier, two voltage-controlled ring oscillators, and a digital control with the total power consumption of 150 μW. The die is assembled with a 2.2 × 2.5-mm2 antenna on PCB, an off-chip decoupling capacitor, an LED, and a photodiode. When the implantable sensor is surrounded by the fluorescent hydrogel and powered by the reader, the frequency of backscattered signals is encoded with the light intensity of the fluorescent glucose sensor, informing the glucose concentration. The miniaturization of the sensor minimizes the invasiveness, the potential discomfort, and immunity reaction against sensor, making it suitable for a long-term use after the implantation.

Original language	English
Title of host publication	2023 IEEE Radio Frequency Integrated Circuits Symposium, RFIC 2023
Editors	Jennifer Kitchen, Steven Turner
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	101-104
Number of pages	4
ISBN (Electronic)	9798350321227
DOIs	https://doi.org/10.1109/RFIC54547.2023.10186146
Publication status	Published - 2023
Event	2023 IEEE Radio Frequency Integrated Circuits Symposium, RFIC 2023 - San Diego, United States Duration: 11 Jun 2023 → 13 Jun 2023

Publication series

Name	Digest of Papers - IEEE Radio Frequency Integrated Circuits Symposium
Volume	2023-June
ISSN (Print)	1529-2517

Conference

Conference	2023 IEEE Radio Frequency Integrated Circuits Symposium, RFIC 2023
Country/Territory	United States
City	San Diego
Period	11/06/23 → 13/06/23

Bibliographical note

Publisher Copyright:
© 2023 IEEE.

Keywords

backscattered modulation
fluorescence hydrogel
implantable glucose sensor
load-shift keying

Access to Document

10.1109/RFIC54547.2023.10186146

Cite this

Lee, H., Park, H., Kim, T., Nam, M. S., Heo, Y. J., & Kim, S. (2023). A mm-sized implantable glucose sensor using a fluorescent hydrogel. In J. Kitchen, & S. Turner (Eds.), 2023 IEEE Radio Frequency Integrated Circuits Symposium, RFIC 2023 (pp. 101-104). (Digest of Papers - IEEE Radio Frequency Integrated Circuits Symposium; Vol. 2023-June). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/RFIC54547.2023.10186146

Lee, Hyeonkeon ; Park, Honghyeon ; Kim, Taein et al. / A mm-sized implantable glucose sensor using a fluorescent hydrogel. 2023 IEEE Radio Frequency Integrated Circuits Symposium, RFIC 2023. editor / Jennifer Kitchen ; Steven Turner. Institute of Electrical and Electronics Engineers Inc., 2023. pp. 101-104 (Digest of Papers - IEEE Radio Frequency Integrated Circuits Symposium).

@inproceedings{228c9db917b542a08834fed13470f0dc,

title = "A mm-sized implantable glucose sensor using a fluorescent hydrogel",

abstract = "This work proposes a millimeter-sized implantable glucose sensor using a fluorescent hydrogel based on boronic acids. The readout system is configured to provide an efficient wireless power transfer to the implantable sensor at 920-MHz frequency. The 675×959-μm2 die fabricated in 180-nm CMOS consists of a rectifier, a bandgap reference, two regulators, a trans-impedance amplifier, two voltage-controlled ring oscillators, and a digital control with the total power consumption of 150 μW. The die is assembled with a 2.2 × 2.5-mm2 antenna on PCB, an off-chip decoupling capacitor, an LED, and a photodiode. When the implantable sensor is surrounded by the fluorescent hydrogel and powered by the reader, the frequency of backscattered signals is encoded with the light intensity of the fluorescent glucose sensor, informing the glucose concentration. The miniaturization of the sensor minimizes the invasiveness, the potential discomfort, and immunity reaction against sensor, making it suitable for a long-term use after the implantation.",

keywords = "backscattered modulation, fluorescence hydrogel, implantable glucose sensor, load-shift keying",

author = "Hyeonkeon Lee and Honghyeon Park and Taein Kim and Nam, \{Mi Song\} and Heo, \{Yun Jung\} and Sanghoek Kim",

note = "Publisher Copyright: {\textcopyright} 2023 IEEE.; 2023 IEEE Radio Frequency Integrated Circuits Symposium, RFIC 2023 ; Conference date: 11-06-2023 Through 13-06-2023",

year = "2023",

doi = "10.1109/RFIC54547.2023.10186146",

language = "English",

series = "Digest of Papers - IEEE Radio Frequency Integrated Circuits Symposium",

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Lee, H, Park, H, Kim, T, Nam, MS, Heo, YJ & Kim, S 2023, A mm-sized implantable glucose sensor using a fluorescent hydrogel. in J Kitchen & S Turner (eds), 2023 IEEE Radio Frequency Integrated Circuits Symposium, RFIC 2023. Digest of Papers - IEEE Radio Frequency Integrated Circuits Symposium, vol. 2023-June, Institute of Electrical and Electronics Engineers Inc., pp. 101-104, 2023 IEEE Radio Frequency Integrated Circuits Symposium, RFIC 2023, San Diego, United States, 11/06/23. https://doi.org/10.1109/RFIC54547.2023.10186146

A mm-sized implantable glucose sensor using a fluorescent hydrogel. / Lee, Hyeonkeon; Park, Honghyeon; Kim, Taein et al.
2023 IEEE Radio Frequency Integrated Circuits Symposium, RFIC 2023. ed. / Jennifer Kitchen; Steven Turner. Institute of Electrical and Electronics Engineers Inc., 2023. p. 101-104 (Digest of Papers - IEEE Radio Frequency Integrated Circuits Symposium; Vol. 2023-June).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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N2 - This work proposes a millimeter-sized implantable glucose sensor using a fluorescent hydrogel based on boronic acids. The readout system is configured to provide an efficient wireless power transfer to the implantable sensor at 920-MHz frequency. The 675×959-μm2 die fabricated in 180-nm CMOS consists of a rectifier, a bandgap reference, two regulators, a trans-impedance amplifier, two voltage-controlled ring oscillators, and a digital control with the total power consumption of 150 μW. The die is assembled with a 2.2 × 2.5-mm2 antenna on PCB, an off-chip decoupling capacitor, an LED, and a photodiode. When the implantable sensor is surrounded by the fluorescent hydrogel and powered by the reader, the frequency of backscattered signals is encoded with the light intensity of the fluorescent glucose sensor, informing the glucose concentration. The miniaturization of the sensor minimizes the invasiveness, the potential discomfort, and immunity reaction against sensor, making it suitable for a long-term use after the implantation.

AB - This work proposes a millimeter-sized implantable glucose sensor using a fluorescent hydrogel based on boronic acids. The readout system is configured to provide an efficient wireless power transfer to the implantable sensor at 920-MHz frequency. The 675×959-μm2 die fabricated in 180-nm CMOS consists of a rectifier, a bandgap reference, two regulators, a trans-impedance amplifier, two voltage-controlled ring oscillators, and a digital control with the total power consumption of 150 μW. The die is assembled with a 2.2 × 2.5-mm2 antenna on PCB, an off-chip decoupling capacitor, an LED, and a photodiode. When the implantable sensor is surrounded by the fluorescent hydrogel and powered by the reader, the frequency of backscattered signals is encoded with the light intensity of the fluorescent glucose sensor, informing the glucose concentration. The miniaturization of the sensor minimizes the invasiveness, the potential discomfort, and immunity reaction against sensor, making it suitable for a long-term use after the implantation.

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Y2 - 11 June 2023 through 13 June 2023

ER -

Lee H, Park H, Kim T, Nam MS, Heo YJ , Kim S. A mm-sized implantable glucose sensor using a fluorescent hydrogel. In Kitchen J, Turner S, editors, 2023 IEEE Radio Frequency Integrated Circuits Symposium, RFIC 2023. Institute of Electrical and Electronics Engineers Inc. 2023. p. 101-104. (Digest of Papers - IEEE Radio Frequency Integrated Circuits Symposium). doi: 10.1109/RFIC54547.2023.10186146

A mm-sized implantable glucose sensor using a fluorescent hydrogel

Abstract

Publication series

Conference

Bibliographical note

Keywords

Access to Document

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