A new flavanone glycoside from the dried immature fruits of Poncirus trifoliata

Ah Reum Han; Jong Bin Kim; Jun Lee; Joo Won Nam; Ik Soo Lee; Chang Koo Shim; Kyung Tae Lee; Eun Kyoung Seo

doi:10.1248/cpb.55.1270

A new flavanone glycoside from the dried immature fruits of Poncirus trifoliata

Ah Reum Han, Jong Bin Kim, Jun Lee, Joo Won Nam, Ik Soo Lee, Chang Koo Shim, Kyung Tae Lee, Eun Kyoung Seo

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A new flavanone glycoside, (2R)-5-hydroxy-4′-methoxyflavanone-7-O- {β-glucopyranosyl-(1→2)-β-glucopyranoside} (1), was isolated from the EtOAc extract of dried immature fruit of Poncirus trifoliata, together with three known compounds, (2S)-poncirin (2), (2S)-naringin (3), and (2S)-poncirenin (4). The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments. Among the isolates, compound 2 exhibited considerable inhibitory activity against lipopolysaccharide (LPS)-induced prostaglandin E₂ (PGE₂) and interleukin-6 (IL-6) production, and mRNA expression in RAW 264.7 murine macrophage cells.

Original language	English
Pages (from-to)	1270-1273
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	55
Issue number	8
DOIs	https://doi.org/10.1248/cpb.55.1270
Publication status	Published - Aug 2007

Keywords

Interleukin-6
New flavanone
Poncirus trifoliata
Prostaglandin E

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title = "A new flavanone glycoside from the dried immature fruits of Poncirus trifoliata",

abstract = "A new flavanone glycoside, (2R)-5-hydroxy-4′-methoxyflavanone-7-O- {β-glucopyranosyl-(1→2)-β-glucopyranoside} (1), was isolated from the EtOAc extract of dried immature fruit of Poncirus trifoliata, together with three known compounds, (2S)-poncirin (2), (2S)-naringin (3), and (2S)-poncirenin (4). The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments. Among the isolates, compound 2 exhibited considerable inhibitory activity against lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2) and interleukin-6 (IL-6) production, and mRNA expression in RAW 264.7 murine macrophage cells.",

keywords = "Interleukin-6, New flavanone, Poncirus trifoliata, Prostaglandin E",

author = "Han, {Ah Reum} and Kim, {Jong Bin} and Jun Lee and Nam, {Joo Won} and Lee, {Ik Soo} and Shim, {Chang Koo} and Lee, {Kyung Tae} and Seo, {Eun Kyoung}",

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AU - Han, Ah Reum

AU - Kim, Jong Bin

AU - Lee, Jun

AU - Nam, Joo Won

AU - Lee, Ik Soo

AU - Shim, Chang Koo

AU - Lee, Kyung Tae

AU - Seo, Eun Kyoung

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KW - Interleukin-6

KW - New flavanone

KW - Poncirus trifoliata

KW - Prostaglandin E

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JO - Chemical and Pharmaceutical Bulletin

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ER -

A new flavanone glycoside from the dried immature fruits of Poncirus trifoliata

Abstract

Keywords

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