A new natural product from the leaves of Olinia usambarensis and evaluation of its constituents for cytotoxicity against human ovarian cancer cells

T. Deyou; J. H. Woo; J. H. Choi; Y. P. Jang

doi:10.1016/j.sajb.2017.08.011

A new natural product from the leaves of Olinia usambarensis and evaluation of its constituents for cytotoxicity against human ovarian cancer cells

T. Deyou
, J. H. Woo
, J. H. Choi
, Y. P. Jang

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Natural products play a significant role in cancer therapy and prevention; with considerable number of anticancer in use are either natural products or their derivatives. In this study, chromatographic separation of CH₂Cl₂/CH₃OH (1:1, v/v) extract of the leaves of Olinia usambarensis gave four compounds among which compound 1, caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one is a new natural product. The structures of the identified compounds were established using spectroscopic and mass spectrometric analyses. The crude extract and isolated compounds were evaluated against the human ovarian cancer cell lines, A2780 and SKOV3, and showed IC₅₀ of 79–170 and 74–136 μM, respectively. The crude extract and isolated compounds were also tested against normal cell, an immortalized ovarian surface epithelial (IOSE) cells, but did not show activity up to 100 μM.

Original language	English
Pages (from-to)	182-185
Number of pages	4
Journal	South African Journal of Botany
Volume	113
DOIs	https://doi.org/10.1016/j.sajb.2017.08.011
Publication status	Published - Nov 2017

Bibliographical note

Publisher Copyright:
© 2017 South African Association of Botanists

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cytotoxicity
Normal cell
Olinia usambarensis
Ovarian cancer cells

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10.1016/j.sajb.2017.08.011

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title = "A new natural product from the leaves of Olinia usambarensis and evaluation of its constituents for cytotoxicity against human ovarian cancer cells",

abstract = "Natural products play a significant role in cancer therapy and prevention; with considerable number of anticancer in use are either natural products or their derivatives. In this study, chromatographic separation of CH2Cl2/CH3OH (1:1, v/v) extract of the leaves of Olinia usambarensis gave four compounds among which compound 1, caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one is a new natural product. The structures of the identified compounds were established using spectroscopic and mass spectrometric analyses. The crude extract and isolated compounds were evaluated against the human ovarian cancer cell lines, A2780 and SKOV3, and showed IC50 of 79{\textendash}170 and 74{\textendash}136 μM, respectively. The crude extract and isolated compounds were also tested against normal cell, an immortalized ovarian surface epithelial (IOSE) cells, but did not show activity up to 100 μM.",

keywords = "Cytotoxicity, Normal cell, Olinia usambarensis, Ovarian cancer cells",

author = "T. Deyou and Woo, \{J. H.\} and Choi, \{J. H.\} and Jang, \{Y. P.\}",

note = "Publisher Copyright: {\textcopyright} 2017 South African Association of Botanists",

year = "2017",

month = nov,

doi = "10.1016/j.sajb.2017.08.011",

language = "English",

volume = "113",

pages = "182--185",

journal = "South African Journal of Botany",

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TY - JOUR

T1 - A new natural product from the leaves of Olinia usambarensis and evaluation of its constituents for cytotoxicity against human ovarian cancer cells

AU - Deyou, T.

AU - Woo, J. H.

AU - Choi, J. H.

AU - Jang, Y. P.

PY - 2017/11

Y1 - 2017/11

N2 - Natural products play a significant role in cancer therapy and prevention; with considerable number of anticancer in use are either natural products or their derivatives. In this study, chromatographic separation of CH2Cl2/CH3OH (1:1, v/v) extract of the leaves of Olinia usambarensis gave four compounds among which compound 1, caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one is a new natural product. The structures of the identified compounds were established using spectroscopic and mass spectrometric analyses. The crude extract and isolated compounds were evaluated against the human ovarian cancer cell lines, A2780 and SKOV3, and showed IC50 of 79–170 and 74–136 μM, respectively. The crude extract and isolated compounds were also tested against normal cell, an immortalized ovarian surface epithelial (IOSE) cells, but did not show activity up to 100 μM.

AB - Natural products play a significant role in cancer therapy and prevention; with considerable number of anticancer in use are either natural products or their derivatives. In this study, chromatographic separation of CH2Cl2/CH3OH (1:1, v/v) extract of the leaves of Olinia usambarensis gave four compounds among which compound 1, caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one is a new natural product. The structures of the identified compounds were established using spectroscopic and mass spectrometric analyses. The crude extract and isolated compounds were evaluated against the human ovarian cancer cell lines, A2780 and SKOV3, and showed IC50 of 79–170 and 74–136 μM, respectively. The crude extract and isolated compounds were also tested against normal cell, an immortalized ovarian surface epithelial (IOSE) cells, but did not show activity up to 100 μM.

KW - Cytotoxicity

KW - Normal cell

KW - Olinia usambarensis

KW - Ovarian cancer cells

UR - https://www.scopus.com/pages/publications/85033698460

U2 - 10.1016/j.sajb.2017.08.011

DO - 10.1016/j.sajb.2017.08.011

M3 - Article

AN - SCOPUS:85033698460

SN - 0254-6299

VL - 113

SP - 182

EP - 185

JO - South African Journal of Botany

JF - South African Journal of Botany

ER -

A new natural product from the leaves of Olinia usambarensis and evaluation of its constituents for cytotoxicity against human ovarian cancer cells

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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