A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population

Dong Hwan Kim; Woo Yong Ahn; Dong Kwan Kim; Bong Keun Choe; Su Kang Kim; Dae Jean Jo; Jae Young Kim; Joo Ho Chung; Yong Seol Jeong; Dong Hwan Yun; Seung Don Yoo; Hee Sang Kim; Hyung Hwan Baik

doi:10.1016/j.plefa.2011.07.004

A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population

Dong Hwan Kim
, Woo Yong Ahn
, Dong Kwan Kim
, Bong Keun Choe
, Su Kang Kim
, Dae Jean Jo
, Jae Young Kim
, Joo Ho Chung
, Yong Seol Jeong
, Dong Hwan Yun
, Seung Don Yoo
, Hee Sang Kim
, Hyung Hwan Baik

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are associated with intracerebral hemorrhage (ICH) and ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (rs434473, Asn322Ser), ALOX5 (rs2228064, Thr90Thr), ALOX5AP (rs17222919, -1316T/G), PTGES (rs7872802, -404A/G), PTGIS (rs5628, Leu256Leu), PTGS1 (rs3842788, Gln41Gln) and PTGS2 (rs5275, 3'UTR). A total of 398 control subjects and 196 stroke patients (79 ICH and 117 IS) were genotyped by direct sequencing. The rs17222919 SNP was associated with ICH in codominant 1 (P=0.008), dominant (P=0.003) and log-additive (P=0.004) models. Allele frequencies of rs17222919 were different between ICH and controls (P=0.007). However, the seven tested SNPs were not associated with clinical phenotypes (NIHSS, MBI and CRPS) in ICH and IS. These results suggest that the promoter SNP rs17222919 of ALOX5AP may be associated with the development of ICH in Korean population.

Original language	English
Pages (from-to)	115-120
Number of pages	6
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	85
Issue number	3-4
DOIs	https://doi.org/10.1016/j.plefa.2011.07.004
Publication status	Published - Sept 2011

Bibliographical note

Funding Information:
This work was supported by the Program of Kyung Hee University for the Young Researcher of Medical Science in 2008 ( KHU-20081275 ).

Keywords

ALOX5AP
Intracerebral hemorrhage
Ischemic stroke
Leukotriene
Polymorphism
Prostaglandin

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10.1016/j.plefa.2011.07.004

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Kim, D. H., Ahn, W. Y., Kim, D. K., Choe, B. K., Kim, S. K., Jo, D. J., Kim, J. Y., Chung, J. H., Jeong, Y. S., Yun, D. H., Yoo, S. D., Kim, H. S., & Baik, H. H. (2011). A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population. Prostaglandins Leukotrienes and Essential Fatty Acids, 85(3-4), 115-120. https://doi.org/10.1016/j.plefa.2011.07.004

@article{87bc67f3c9c4420ea30c656a6a365e5a,

title = "A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population",

abstract = "To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are associated with intracerebral hemorrhage (ICH) and ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (rs434473, Asn322Ser), ALOX5 (rs2228064, Thr90Thr), ALOX5AP (rs17222919, -1316T/G), PTGES (rs7872802, -404A/G), PTGIS (rs5628, Leu256Leu), PTGS1 (rs3842788, Gln41Gln) and PTGS2 (rs5275, 3'UTR). A total of 398 control subjects and 196 stroke patients (79 ICH and 117 IS) were genotyped by direct sequencing. The rs17222919 SNP was associated with ICH in codominant 1 (P=0.008), dominant (P=0.003) and log-additive (P=0.004) models. Allele frequencies of rs17222919 were different between ICH and controls (P=0.007). However, the seven tested SNPs were not associated with clinical phenotypes (NIHSS, MBI and CRPS) in ICH and IS. These results suggest that the promoter SNP rs17222919 of ALOX5AP may be associated with the development of ICH in Korean population.",

keywords = "ALOX5AP, Intracerebral hemorrhage, Ischemic stroke, Leukotriene, Polymorphism, Prostaglandin",

author = "Kim, \{Dong Hwan\} and Ahn, \{Woo Yong\} and Kim, \{Dong Kwan\} and Choe, \{Bong Keun\} and Kim, \{Su Kang\} and Jo, \{Dae Jean\} and Kim, \{Jae Young\} and Chung, \{Joo Ho\} and Jeong, \{Yong Seol\} and Yun, \{Dong Hwan\} and Yoo, \{Seung Don\} and Kim, \{Hee Sang\} and Baik, \{Hyung Hwan\}",

note = "Funding Information: This work was supported by the Program of Kyung Hee University for the Young Researcher of Medical Science in 2008 ( KHU-20081275 ).",

year = "2011",

month = sep,

doi = "10.1016/j.plefa.2011.07.004",

language = "English",

volume = "85",

pages = "115--120",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

issn = "0952-3278",

publisher = "Churchill Livingstone",

number = "3-4",

}

Kim, DH, Ahn, WY, Kim, DK, Choe, BK, Kim, SK, Jo, DJ, Kim, JY, Chung, JH, Jeong, YS, Yun, DH , Yoo, SD, Kim, HS & Baik, HH 2011, 'A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 85, no. 3-4, pp. 115-120. https://doi.org/10.1016/j.plefa.2011.07.004

TY - JOUR

T1 - A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population

AU - Kim, Dong Hwan

AU - Ahn, Woo Yong

AU - Kim, Dong Kwan

AU - Choe, Bong Keun

AU - Kim, Su Kang

AU - Jo, Dae Jean

AU - Kim, Jae Young

AU - Chung, Joo Ho

AU - Jeong, Yong Seol

AU - Yun, Dong Hwan

AU - Yoo, Seung Don

AU - Kim, Hee Sang

AU - Baik, Hyung Hwan

N1 - Funding Information: This work was supported by the Program of Kyung Hee University for the Young Researcher of Medical Science in 2008 ( KHU-20081275 ).

PY - 2011/9

Y1 - 2011/9

N2 - To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are associated with intracerebral hemorrhage (ICH) and ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (rs434473, Asn322Ser), ALOX5 (rs2228064, Thr90Thr), ALOX5AP (rs17222919, -1316T/G), PTGES (rs7872802, -404A/G), PTGIS (rs5628, Leu256Leu), PTGS1 (rs3842788, Gln41Gln) and PTGS2 (rs5275, 3'UTR). A total of 398 control subjects and 196 stroke patients (79 ICH and 117 IS) were genotyped by direct sequencing. The rs17222919 SNP was associated with ICH in codominant 1 (P=0.008), dominant (P=0.003) and log-additive (P=0.004) models. Allele frequencies of rs17222919 were different between ICH and controls (P=0.007). However, the seven tested SNPs were not associated with clinical phenotypes (NIHSS, MBI and CRPS) in ICH and IS. These results suggest that the promoter SNP rs17222919 of ALOX5AP may be associated with the development of ICH in Korean population.

AB - To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are associated with intracerebral hemorrhage (ICH) and ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (rs434473, Asn322Ser), ALOX5 (rs2228064, Thr90Thr), ALOX5AP (rs17222919, -1316T/G), PTGES (rs7872802, -404A/G), PTGIS (rs5628, Leu256Leu), PTGS1 (rs3842788, Gln41Gln) and PTGS2 (rs5275, 3'UTR). A total of 398 control subjects and 196 stroke patients (79 ICH and 117 IS) were genotyped by direct sequencing. The rs17222919 SNP was associated with ICH in codominant 1 (P=0.008), dominant (P=0.003) and log-additive (P=0.004) models. Allele frequencies of rs17222919 were different between ICH and controls (P=0.007). However, the seven tested SNPs were not associated with clinical phenotypes (NIHSS, MBI and CRPS) in ICH and IS. These results suggest that the promoter SNP rs17222919 of ALOX5AP may be associated with the development of ICH in Korean population.

KW - ALOX5AP

KW - Intracerebral hemorrhage

KW - Ischemic stroke

KW - Leukotriene

KW - Polymorphism

KW - Prostaglandin

UR - https://www.scopus.com/pages/publications/80052271965

U2 - 10.1016/j.plefa.2011.07.004

DO - 10.1016/j.plefa.2011.07.004

M3 - Article

C2 - 21816595

AN - SCOPUS:80052271965

SN - 0952-3278

VL - 85

SP - 115

EP - 120

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

IS - 3-4

ER -

A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population

Abstract

Bibliographical note

Keywords

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