Abstract
We investigated the effects of the aqueous extract of Solanum lyratum THUNB. (Solanaceae) (SLAE) on the anaphylactic reactions. SLAE inhibited compound 48/80-induced anaphylactic shock 100% with a dose of 1.0 mg/g body weight (BW). When SLAE was pretreated at concentration ranging from 0.0001- 1.0 mg/g BW, the serum histamine levels were reduced in a dose-dependent manner. Passive cutaneous anaphylaxis also inhibited to 69.3% by oral administration of SLAE (0.05 mg/g Bw). Moreover, SLAE dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when SLAE was added, significantly increased compared with that of normal control. These results indicate that SLAE possess strong antianaphylactic activity.
| Original language | English |
|---|---|
| Pages (from-to) | 729-734 |
| Number of pages | 6 |
| Journal | International Journal of Immunopharmacology |
| Volume | 19 |
| Issue number | 11-12 |
| DOIs | |
| Publication status | Published - 5 Jun 1998 |
Bibliographical note
Funding Information:This study is supported by the academic research fund of Ministry of Education, Republic of Korea.
Keywords
- (Solanaceae)
- Anaphylactic shock
- CAMP
- Histamine
- Passive anaphylaxis
- Solanum lyratum THUNB
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