Abstract
To assess the contribution of an aqueous extract of Ulmi radicis cortex (AEURC) in systemic anaphylaxis, compound 48/80 was used as a fatal anaphylaxis inducer in rats.AEURC completely inhibited anaphylactic shock with a dose of 1.0 g/kg body weight (BW) 1 hr before injection of compound 48/80.AEURC significantly inhibited serum histamine levels induced by compound 48/80.AEURC (1.0 g/kg BW) also inhibited by 79.1% passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE.AEURC dose dependently inhibited the histamine release from the rat peritoneal mast cells (RPMCs) by compound 48/80. Moreover, AEURC had a significant inhibitory effect on anti-DNP IgE-induced histamine release and tumor necrosis factor-α production from RPMC.The level of cAMP in RPMC, when AEURC was added, significantly increased compared with that of a normal control.These results indicate that AEURC may possess strong antianaphylactic action. Copyright (C) 1998 Elsevier Science Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 483-488 |
| Number of pages | 6 |
| Journal | General Pharmacology: The Vascular System |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sept 1998 |
Bibliographical note
Funding Information:This research was supported by Wonkwang University in 1997.
Keywords
- Anaphylaxis
- Anti-dinitrophenyl IgE
- Compound 48/80
- Histamine
- Tumor necrosis factor-α
- Ulmi radicis
- cAMP
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