AEG-1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases

L. Emdad; S. K. Das; B. Hu; T. Kegelman; D. C. Kang; S. G. Lee; D. Sarkar; P. B. Fisher

doi:10.1016/bs.acr.2016.05.002

AEG-1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases

L. Emdad, S. K. Das, B. Hu, T. Kegelman, D. C. Kang, S. G. Lee, D. Sarkar, P. B. Fisher

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

34 Citations (Scopus)

Abstract

Since its original discovery in 2002, AEG-1/MTDH/LYRIC has emerged as a primary regulator of several diseases including cancer, inflammatory diseases, and neurodegenerative diseases. AEG-1/MTDH/LYRIC has emerged as a key contributory molecule in almost every aspect of cancer progression, including uncontrolled cell growth, evasion of apoptosis, increased cell migration and invasion, angiogenesis, chemoresistance, and metastasis. Additionally, recent studies highlight a seminal role of AEG-1/MTDH/LYRIC in neurodegenerative diseases and obesity. By interacting with multiple protein partners, AEG-1/MTDH/LYRIC plays multifaceted roles in the pathogenesis of a wide variety of diseases. This review discusses the current state of understanding of AEG-1/MTDH/LYRIC regulation and function in cancer and other diseases with a focus on its association/interaction with several pivotal protein partners.

Original language	English
Title of host publication	Advances in Cancer Research, 2016
Editors	Kenneth D. Tew, Paul B. Fisher, Paul B. Fisher
Publisher	Academic Press Inc.
Pages	97-132
Number of pages	36
ISBN (Print)	9780128047880
DOIs	https://doi.org/10.1016/bs.acr.2016.05.002
Publication status	Published - 2016

Publication series

Name	Advances in Cancer Research
Volume	131
ISSN (Print)	0065-230X
ISSN (Electronic)	2162-5557

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

AEG-1/MTDH/LYRIC
CNS diseases
Cancer aggressiveness
Interacting proteins
Obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/bs.acr.2016.05.002

Cite this

Emdad, L., Das, S. K., Hu, B., Kegelman, T., Kang, D. C., Lee, S. G., Sarkar, D., & Fisher, P. B. (2016). AEG-1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases. In K. D. Tew, P. B. Fisher, & P. B. Fisher (Eds.), Advances in Cancer Research, 2016 (pp. 97-132). (Advances in Cancer Research; Vol. 131). Academic Press Inc.. https://doi.org/10.1016/bs.acr.2016.05.002

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abstract = "Since its original discovery in 2002, AEG-1/MTDH/LYRIC has emerged as a primary regulator of several diseases including cancer, inflammatory diseases, and neurodegenerative diseases. AEG-1/MTDH/LYRIC has emerged as a key contributory molecule in almost every aspect of cancer progression, including uncontrolled cell growth, evasion of apoptosis, increased cell migration and invasion, angiogenesis, chemoresistance, and metastasis. Additionally, recent studies highlight a seminal role of AEG-1/MTDH/LYRIC in neurodegenerative diseases and obesity. By interacting with multiple protein partners, AEG-1/MTDH/LYRIC plays multifaceted roles in the pathogenesis of a wide variety of diseases. This review discusses the current state of understanding of AEG-1/MTDH/LYRIC regulation and function in cancer and other diseases with a focus on its association/interaction with several pivotal protein partners.",

keywords = "AEG-1/MTDH/LYRIC, CNS diseases, Cancer aggressiveness, Interacting proteins, Obesity",

author = "L. Emdad and Das, {S. K.} and B. Hu and T. Kegelman and Kang, {D. C.} and Lee, {S. G.} and D. Sarkar and Fisher, {P. B.}",

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year = "2016",

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language = "English",

isbn = "9780128047880",

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Emdad, L, Das, SK, Hu, B, Kegelman, T, Kang, DC, Lee, SG, Sarkar, D & Fisher, PB 2016, AEG-1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases. in KD Tew, PB Fisher & PB Fisher (eds), Advances in Cancer Research, 2016. Advances in Cancer Research, vol. 131, Academic Press Inc., pp. 97-132. https://doi.org/10.1016/bs.acr.2016.05.002

AEG-1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases. / Emdad, L.; Das, S. K.; Hu, B. et al.
Advances in Cancer Research, 2016. ed. / Kenneth D. Tew; Paul B. Fisher; Paul B. Fisher. Academic Press Inc., 2016. p. 97-132 (Advances in Cancer Research; Vol. 131).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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ER -

AEG-1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases

Abstract

Publication series

Bibliographical note

Keywords

UN SDGs

Access to Document

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