AEG-1/MTDH/LYRIC, the Beginning: Initial cloning, structure, expression profile, and regulation of expression.

Seok Geun Lee; Dong Chul Kang; Rob DeSalle; Devanand Sarkar; Paul B. Fisher

doi:10.1016/B978-0-12-401676-7.00001-2

AEG-1/MTDH/LYRIC, the Beginning: Initial cloning, structure, expression profile, and regulation of expression.

Seok Geun Lee, Dong Chul Kang, Rob DeSalle, Devanand Sarkar, Paul B. Fisher

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

59 Citations (Scopus)

Abstract

Since its initial identification as a HIV-1-inducible gene in 2002, astrocyte elevated gene-1 (AEG-1), subsequently cloned as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), has emerged over the past 10 years as an important oncogene providing a valuable prognostic marker in patients with various cancers. Recent studies demonstrate that AEG-1/MTDH/LYRIC is a pleiotropic protein that can localize in the cell membrane, cytoplasm, endoplasmic reticulum (ER), nucleus, and nucleolus, and contributes to diverse signaling pathways such as PI3K-AKT, NF-κB, MAPK, and Wnt. In addition to tumorigenesis, this multifunctional protein is implicated in various physiological and pathological processes including development, neurodegeneration, and inflammation. The present review focuses on the discovery of AEG-1/MTDH/LYRIC and conceptualizes areas of future direction for this intriguing gene. We begin by describing how AEG-1, MTDH, and LYRIC were initially identified by different research groups and then discuss AEG-1 structure, functions, localization, and evolution. We conclude with a discussion of the expression profile of AEG-1/MTDH/LYRIC in the context of cancer, neurological disorders, inflammation, and embryogenesis, and discuss how AEG-1/MTDH/LYRIC is regulated. This introductory discussion of AEG-1/MTDH/LYRIC will serve as the basis for the detailed discussions in other chapters of the unique properties of this intriguing molecule.

Original language	English
Title of host publication	Advances in Cancer Research
Publisher	Academic Press Inc.
Pages	1-38
Number of pages	38
DOIs	https://doi.org/10.1016/B978-0-12-401676-7.00001-2
Publication status	Published - 2013

Publication series

Name	Advances in Cancer Research
Volume	120
ISSN (Print)	0065-230X

Bibliographical note

Funding Information:
We are indebted to the National Institutes of Health, including the National Cancer Institute Grant 1 R01 CA134721, National Institute of Neurological Disease and Stroke, 5 P01 NS31492, and the Thelma Newmeyer Corman Endowment to P. B. F., by National Cancer Institute Grant R01 CA138540 to D. S., by HRF-G-2012-6 to D. K. from Hallym University, and by a National Research Foundation of Korea grant (No. 2012-0005755) to S.-G. L. D. S. is a Harrison Scholar in the VCU Massey Cancer Center. P. B. F. holds the Thelma Newmeyer Corman Endowed Chair in Cancer Research at the VCU Massey Cancer Center.

Keywords

AEG-1/MTDH/LYRIC
C-Myc
Cloning
HIV
Ha-ras
PI3K/AKT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-401676-7.00001-2

Cite this

@inbook{eb75abb672f54935b91b06f4e3ce7a12,

title = "AEG-1/MTDH/LYRIC, the Beginning: Initial cloning, structure, expression profile, and regulation of expression.",

abstract = "Since its initial identification as a HIV-1-inducible gene in 2002, astrocyte elevated gene-1 (AEG-1), subsequently cloned as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), has emerged over the past 10 years as an important oncogene providing a valuable prognostic marker in patients with various cancers. Recent studies demonstrate that AEG-1/MTDH/LYRIC is a pleiotropic protein that can localize in the cell membrane, cytoplasm, endoplasmic reticulum (ER), nucleus, and nucleolus, and contributes to diverse signaling pathways such as PI3K-AKT, NF-κB, MAPK, and Wnt. In addition to tumorigenesis, this multifunctional protein is implicated in various physiological and pathological processes including development, neurodegeneration, and inflammation. The present review focuses on the discovery of AEG-1/MTDH/LYRIC and conceptualizes areas of future direction for this intriguing gene. We begin by describing how AEG-1, MTDH, and LYRIC were initially identified by different research groups and then discuss AEG-1 structure, functions, localization, and evolution. We conclude with a discussion of the expression profile of AEG-1/MTDH/LYRIC in the context of cancer, neurological disorders, inflammation, and embryogenesis, and discuss how AEG-1/MTDH/LYRIC is regulated. This introductory discussion of AEG-1/MTDH/LYRIC will serve as the basis for the detailed discussions in other chapters of the unique properties of this intriguing molecule.",

keywords = "AEG-1/MTDH/LYRIC, C-Myc, Cloning, HIV, Ha-ras, PI3K/AKT",

author = "Lee, {Seok Geun} and Kang, {Dong Chul} and Rob DeSalle and Devanand Sarkar and Fisher, {Paul B.}",

note = "Funding Information: We are indebted to the National Institutes of Health, including the National Cancer Institute Grant 1 R01 CA134721, National Institute of Neurological Disease and Stroke, 5 P01 NS31492, and the Thelma Newmeyer Corman Endowment to P. B. F., by National Cancer Institute Grant R01 CA138540 to D. S., by HRF-G-2012-6 to D. K. from Hallym University, and by a National Research Foundation of Korea grant (No. 2012-0005755) to S.-G. L. D. S. is a Harrison Scholar in the VCU Massey Cancer Center. P. B. F. holds the Thelma Newmeyer Corman Endowed Chair in Cancer Research at the VCU Massey Cancer Center.",

year = "2013",

doi = "10.1016/B978-0-12-401676-7.00001-2",

language = "English",

series = "Advances in Cancer Research",

publisher = "Academic Press Inc.",

pages = "1--38",

booktitle = "Advances in Cancer Research",

address = "United States",

}

TY - CHAP

T1 - AEG-1/MTDH/LYRIC, the Beginning

T2 - Initial cloning, structure, expression profile, and regulation of expression.

AU - Lee, Seok Geun

AU - Kang, Dong Chul

AU - DeSalle, Rob

AU - Sarkar, Devanand

AU - Fisher, Paul B.

N1 - Funding Information: We are indebted to the National Institutes of Health, including the National Cancer Institute Grant 1 R01 CA134721, National Institute of Neurological Disease and Stroke, 5 P01 NS31492, and the Thelma Newmeyer Corman Endowment to P. B. F., by National Cancer Institute Grant R01 CA138540 to D. S., by HRF-G-2012-6 to D. K. from Hallym University, and by a National Research Foundation of Korea grant (No. 2012-0005755) to S.-G. L. D. S. is a Harrison Scholar in the VCU Massey Cancer Center. P. B. F. holds the Thelma Newmeyer Corman Endowed Chair in Cancer Research at the VCU Massey Cancer Center.

PY - 2013

Y1 - 2013

N2 - Since its initial identification as a HIV-1-inducible gene in 2002, astrocyte elevated gene-1 (AEG-1), subsequently cloned as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), has emerged over the past 10 years as an important oncogene providing a valuable prognostic marker in patients with various cancers. Recent studies demonstrate that AEG-1/MTDH/LYRIC is a pleiotropic protein that can localize in the cell membrane, cytoplasm, endoplasmic reticulum (ER), nucleus, and nucleolus, and contributes to diverse signaling pathways such as PI3K-AKT, NF-κB, MAPK, and Wnt. In addition to tumorigenesis, this multifunctional protein is implicated in various physiological and pathological processes including development, neurodegeneration, and inflammation. The present review focuses on the discovery of AEG-1/MTDH/LYRIC and conceptualizes areas of future direction for this intriguing gene. We begin by describing how AEG-1, MTDH, and LYRIC were initially identified by different research groups and then discuss AEG-1 structure, functions, localization, and evolution. We conclude with a discussion of the expression profile of AEG-1/MTDH/LYRIC in the context of cancer, neurological disorders, inflammation, and embryogenesis, and discuss how AEG-1/MTDH/LYRIC is regulated. This introductory discussion of AEG-1/MTDH/LYRIC will serve as the basis for the detailed discussions in other chapters of the unique properties of this intriguing molecule.

AB - Since its initial identification as a HIV-1-inducible gene in 2002, astrocyte elevated gene-1 (AEG-1), subsequently cloned as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), has emerged over the past 10 years as an important oncogene providing a valuable prognostic marker in patients with various cancers. Recent studies demonstrate that AEG-1/MTDH/LYRIC is a pleiotropic protein that can localize in the cell membrane, cytoplasm, endoplasmic reticulum (ER), nucleus, and nucleolus, and contributes to diverse signaling pathways such as PI3K-AKT, NF-κB, MAPK, and Wnt. In addition to tumorigenesis, this multifunctional protein is implicated in various physiological and pathological processes including development, neurodegeneration, and inflammation. The present review focuses on the discovery of AEG-1/MTDH/LYRIC and conceptualizes areas of future direction for this intriguing gene. We begin by describing how AEG-1, MTDH, and LYRIC were initially identified by different research groups and then discuss AEG-1 structure, functions, localization, and evolution. We conclude with a discussion of the expression profile of AEG-1/MTDH/LYRIC in the context of cancer, neurological disorders, inflammation, and embryogenesis, and discuss how AEG-1/MTDH/LYRIC is regulated. This introductory discussion of AEG-1/MTDH/LYRIC will serve as the basis for the detailed discussions in other chapters of the unique properties of this intriguing molecule.

KW - AEG-1/MTDH/LYRIC

KW - C-Myc

KW - Cloning

KW - HIV

KW - Ha-ras

KW - PI3K/AKT

UR - http://www.scopus.com/inward/record.url?scp=84880927036&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-401676-7.00001-2

DO - 10.1016/B978-0-12-401676-7.00001-2

M3 - Chapter

C2 - 23889986

AN - SCOPUS:84880927036

T3 - Advances in Cancer Research

SP - 1

EP - 38

BT - Advances in Cancer Research

PB - Academic Press Inc.

ER -

AEG-1/MTDH/LYRIC, the Beginning: Initial cloning, structure, expression profile, and regulation of expression.

Abstract

Publication series

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this