An acetylcholinesterase inhibitor from the leaves of Securinega suffruticosa

Choon Hee Jang; Jae Soon Eun; Hye Won Park; Seon Mi Seo; Jae Heon Yang; Kang Hyun Leem; Seok Heung Oh; Chan Ho Oh; Nam In Baek; Dae Keun Kim

An acetylcholinesterase inhibitor from the leaves of Securinega suffruticosa

Choon Hee Jang
, Jae Soon Eun
, Hye Won Park
, Seon Mi Seo
, Jae Heon Yang
, Kang Hyun Leem
, Seok Heung Oh
, Chan Ho Oh
, Nam In Baek
, Dae Keun Kim

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

In the course of screening Korean natural plants for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the leaves of Securinega suffruticosa showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of dihydrosecurinine, as a active principle. This compound inhibited AChE activity in a dose-dependent manner, and the IC₅₀ value of dihydrosecurinine was 18.9 μg.

Original language	English
Pages (from-to)	14-17
Number of pages	4
Journal	Korean Journal of Pharmacognosy
Volume	34
Issue number	1
Publication status	Published - Mar 2003

Keywords

Acetylcholinesterase
Dihydrosecurinine
Securinega suffruticosa

Cite this

@article{2104e47f356d491184f888246ba9c8ad,

title = "An acetylcholinesterase inhibitor from the leaves of Securinega suffruticosa",

abstract = "In the course of screening Korean natural plants for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the leaves of Securinega suffruticosa showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of dihydrosecurinine, as a active principle. This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of dihydrosecurinine was 18.9 μg.",

keywords = "Acetylcholinesterase, Dihydrosecurinine, Securinega suffruticosa",

author = "Jang, \{Choon Hee\} and Eun, \{Jae Soon\} and Park, \{Hye Won\} and Seo, \{Seon Mi\} and Yang, \{Jae Heon\} and Leem, \{Kang Hyun\} and Oh, \{Seok Heung\} and Oh, \{Chan Ho\} and Baek, \{Nam In\} and Kim, \{Dae Keun\}",

year = "2003",

month = mar,

language = "English",

volume = "34",

pages = "14--17",

journal = "Korean Journal of Pharmacognosy",

issn = "0253-3073",

publisher = "Korean Society of Pharmacognosy",

number = "1",

}

TY - JOUR

T1 - An acetylcholinesterase inhibitor from the leaves of Securinega suffruticosa

AU - Jang, Choon Hee

AU - Eun, Jae Soon

AU - Park, Hye Won

AU - Seo, Seon Mi

AU - Yang, Jae Heon

AU - Leem, Kang Hyun

AU - Oh, Seok Heung

AU - Oh, Chan Ho

AU - Baek, Nam In

AU - Kim, Dae Keun

PY - 2003/3

Y1 - 2003/3

N2 - In the course of screening Korean natural plants for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the leaves of Securinega suffruticosa showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of dihydrosecurinine, as a active principle. This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of dihydrosecurinine was 18.9 μg.

AB - In the course of screening Korean natural plants for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the leaves of Securinega suffruticosa showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of dihydrosecurinine, as a active principle. This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of dihydrosecurinine was 18.9 μg.

KW - Acetylcholinesterase

KW - Dihydrosecurinine

KW - Securinega suffruticosa

UR - https://www.scopus.com/pages/publications/0037361165

M3 - Article

AN - SCOPUS:0037361165

SN - 0253-3073

VL - 34

SP - 14

EP - 17

JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

IS - 1

ER -

An acetylcholinesterase inhibitor from the leaves of Securinega suffruticosa

Abstract

Keywords

Other files and links

Fingerprint

Cite this