An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases

Tae Il Kim; Myeong Seon Jeong; Sang J. Chung; Youngmi Kim

doi:10.1002/chem.201000154

An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases

Tae Il Kim, Myeong Seon Jeong, Sang J. Chung, Youngmi Kim

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

(Figure Presented) Seeing is believing: A fluorescent probe for monitoring the activity of dual-specific protein tyrosine phosphatases (PTPs) has been developed (see scheme). Selective enzymatic hydrolysis and subsequent intramolecular cyclization results in a highly fluorescent iminocoumarin fluorophore.

Original language	English
Pages (from-to)	5297-5300
Number of pages	4
Journal	Chemistry - A European Journal
Volume	16
Issue number	18
DOIs	https://doi.org/10.1002/chem.201000154
Publication status	Published - 10 May 2010

Keywords

Cyclization
Dual specificity
Fluorescent probes
Protein tyrosine phosphatases

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10.1002/chem.201000154

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title = "An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases",

abstract = "(Figure Presented) Seeing is believing: A fluorescent probe for monitoring the activity of dual-specific protein tyrosine phosphatases (PTPs) has been developed (see scheme). Selective enzymatic hydrolysis and subsequent intramolecular cyclization results in a highly fluorescent iminocoumarin fluorophore.",

keywords = "Cyclization, Dual specificity, Fluorescent probes, Protein tyrosine phosphatases",

author = "Kim, {Tae Il} and Jeong, {Myeong Seon} and Chung, {Sang J.} and Youngmi Kim",

year = "2010",

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AU - Kim, Tae Il

AU - Jeong, Myeong Seon

AU - Chung, Sang J.

AU - Kim, Youngmi

PY - 2010/5/10

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N2 - (Figure Presented) Seeing is believing: A fluorescent probe for monitoring the activity of dual-specific protein tyrosine phosphatases (PTPs) has been developed (see scheme). Selective enzymatic hydrolysis and subsequent intramolecular cyclization results in a highly fluorescent iminocoumarin fluorophore.

AB - (Figure Presented) Seeing is believing: A fluorescent probe for monitoring the activity of dual-specific protein tyrosine phosphatases (PTPs) has been developed (see scheme). Selective enzymatic hydrolysis and subsequent intramolecular cyclization results in a highly fluorescent iminocoumarin fluorophore.

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KW - Dual specificity

KW - Fluorescent probes

KW - Protein tyrosine phosphatases

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M3 - Article

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

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ER -

An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases

Abstract

Keywords

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