An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases

Tae Il Kim, Myeong Seon Jeong, Sang J. Chung, Youngmi Kim

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

(Figure Presented) Seeing is believing: A fluorescent probe for monitoring the activity of dual-specific protein tyrosine phosphatases (PTPs) has been developed (see scheme). Selective enzymatic hydrolysis and subsequent intramolecular cyclization results in a highly fluorescent iminocoumarin fluorophore.

Original languageEnglish
Pages (from-to)5297-5300
Number of pages4
JournalChemistry - A European Journal
Volume16
Issue number18
DOIs
Publication statusPublished - 10 May 2010

Keywords

  • Cyclization
  • Dual specificity
  • Fluorescent probes
  • Protein tyrosine phosphatases

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