An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time

Kyeongha Kwon; Jong Uk Kim; Yujun Deng; Siddharth R. Krishnan; Jungil Choi; Hokyung Jang; Kun Hyuck Lee; Chun Ju Su; Injae Yoo; Yixin Wu; Lindsay Lipschultz; Jae Hwan Kim; Ted S. Chung; Derek Wu; Yoonseok Park; Tae il Kim; Roozbeh Ghaffari; Stephen Lee; Yonggang Huang; John A. Rogers

doi:10.1038/s41928-021-00556-2

An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time

Kyeongha Kwon, Jong Uk Kim, Yujun Deng, Siddharth R. Krishnan, Jungil Choi, Hokyung Jang, Kun Hyuck Lee, Chun Ju Su, Injae Yoo, Yixin Wu, Lindsay Lipschultz, Jae Hwan Kim, Ted S. Chung, Derek Wu, Yoonseok Park, Tae il Kim, Roozbeh Ghaffari, Stephen Lee, Yonggang Huang, John A. Rogers

Research output: Contribution to journal › Article › peer-review

155 Citations (Scopus)

Abstract

Monitoring the flow rate, cumulative loss and temperature of sweat can provide valuable physiological insights for the diagnosis of thermoregulatory disorders and illnesses related to heat stress. However, obtaining accurate, continuous estimates of these parameters with high temporal resolution remains challenging. Here, we report a platform that can wirelessly measure sweat rate, sweat loss and skin temperature in real time. The approach combines a short, straight fluid passage to capture sweat as it emerges from the skin with a flow sensor that is based on a thermal actuator and precision thermistors, and that is physically isolated from, but thermally coupled to, the sweat. The platform transfers data autonomously using a Bluetooth Low Energy system on a chip. Our approach can also be integrated with advanced microfluidic systems and colorimetric chemical reagents for the measurement of pH and the concentration of chloride, creatinine and glucose in sweat.

Original language	English
Pages (from-to)	302-312
Number of pages	11
Journal	Nature Electronics
Volume	4
Issue number	4
DOIs	https://doi.org/10.1038/s41928-021-00556-2
Publication status	Published - Apr 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited.

Access to Document

10.1038/s41928-021-00556-2

Cite this

Kwon, K., Kim, J. U., Deng, Y., Krishnan, S. R., Choi, J., Jang, H., Lee, K. H., Su, C. J., Yoo, I., Wu, Y., Lipschultz, L., Kim, J. H., Chung, T. S., Wu, D., Park, Y., Kim, T. I., Ghaffari, R., Lee, S., Huang, Y., & Rogers, J. A. (2021). An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time. Nature Electronics, 4(4), 302-312. https://doi.org/10.1038/s41928-021-00556-2

@article{3be6394f0e924c4d898029d03f2edb06,

title = "An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time",

abstract = "Monitoring the flow rate, cumulative loss and temperature of sweat can provide valuable physiological insights for the diagnosis of thermoregulatory disorders and illnesses related to heat stress. However, obtaining accurate, continuous estimates of these parameters with high temporal resolution remains challenging. Here, we report a platform that can wirelessly measure sweat rate, sweat loss and skin temperature in real time. The approach combines a short, straight fluid passage to capture sweat as it emerges from the skin with a flow sensor that is based on a thermal actuator and precision thermistors, and that is physically isolated from, but thermally coupled to, the sweat. The platform transfers data autonomously using a Bluetooth Low Energy system on a chip. Our approach can also be integrated with advanced microfluidic systems and colorimetric chemical reagents for the measurement of pH and the concentration of chloride, creatinine and glucose in sweat.",

author = "Kyeongha Kwon and Kim, {Jong Uk} and Yujun Deng and Krishnan, {Siddharth R.} and Jungil Choi and Hokyung Jang and Lee, {Kun Hyuck} and Su, {Chun Ju} and Injae Yoo and Yixin Wu and Lindsay Lipschultz and Kim, {Jae Hwan} and Chung, {Ted S.} and Derek Wu and Yoonseok Park and Kim, {Tae il} and Roozbeh Ghaffari and Stephen Lee and Yonggang Huang and Rogers, {John A.}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2021",

month = apr,

doi = "10.1038/s41928-021-00556-2",

language = "English",

volume = "4",

pages = "302--312",

journal = "Nature Electronics",

issn = "2520-1131",

publisher = "Nature Publishing Group",

number = "4",

}

Kwon, K, Kim, JU, Deng, Y, Krishnan, SR, Choi, J, Jang, H, Lee, KH, Su, CJ, Yoo, I, Wu, Y, Lipschultz, L, Kim, JH, Chung, TS, Wu, D, Park, Y, Kim, TI, Ghaffari, R, Lee, S, Huang, Y & Rogers, JA 2021, 'An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time', Nature Electronics, vol. 4, no. 4, pp. 302-312. https://doi.org/10.1038/s41928-021-00556-2

TY - JOUR

T1 - An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time

AU - Kwon, Kyeongha

AU - Kim, Jong Uk

AU - Deng, Yujun

AU - Krishnan, Siddharth R.

AU - Choi, Jungil

AU - Jang, Hokyung

AU - Lee, Kun Hyuck

AU - Su, Chun Ju

AU - Yoo, Injae

AU - Wu, Yixin

AU - Lipschultz, Lindsay

AU - Kim, Jae Hwan

AU - Chung, Ted S.

AU - Wu, Derek

AU - Park, Yoonseok

AU - Kim, Tae il

AU - Ghaffari, Roozbeh

AU - Lee, Stephen

AU - Huang, Yonggang

AU - Rogers, John A.

PY - 2021/4

Y1 - 2021/4

N2 - Monitoring the flow rate, cumulative loss and temperature of sweat can provide valuable physiological insights for the diagnosis of thermoregulatory disorders and illnesses related to heat stress. However, obtaining accurate, continuous estimates of these parameters with high temporal resolution remains challenging. Here, we report a platform that can wirelessly measure sweat rate, sweat loss and skin temperature in real time. The approach combines a short, straight fluid passage to capture sweat as it emerges from the skin with a flow sensor that is based on a thermal actuator and precision thermistors, and that is physically isolated from, but thermally coupled to, the sweat. The platform transfers data autonomously using a Bluetooth Low Energy system on a chip. Our approach can also be integrated with advanced microfluidic systems and colorimetric chemical reagents for the measurement of pH and the concentration of chloride, creatinine and glucose in sweat.

AB - Monitoring the flow rate, cumulative loss and temperature of sweat can provide valuable physiological insights for the diagnosis of thermoregulatory disorders and illnesses related to heat stress. However, obtaining accurate, continuous estimates of these parameters with high temporal resolution remains challenging. Here, we report a platform that can wirelessly measure sweat rate, sweat loss and skin temperature in real time. The approach combines a short, straight fluid passage to capture sweat as it emerges from the skin with a flow sensor that is based on a thermal actuator and precision thermistors, and that is physically isolated from, but thermally coupled to, the sweat. The platform transfers data autonomously using a Bluetooth Low Energy system on a chip. Our approach can also be integrated with advanced microfluidic systems and colorimetric chemical reagents for the measurement of pH and the concentration of chloride, creatinine and glucose in sweat.

UR - http://www.scopus.com/inward/record.url?scp=85103399374&partnerID=8YFLogxK

U2 - 10.1038/s41928-021-00556-2

DO - 10.1038/s41928-021-00556-2

M3 - Article

AN - SCOPUS:85103399374

SN - 2520-1131

VL - 4

SP - 302

EP - 312

JO - Nature Electronics

JF - Nature Electronics

IS - 4

ER -

An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this