TY - JOUR
T1 - Analytical Methods for Detection of Gasotransmitter Hydrogen Sulfide Released from Live Cells
AU - Quan, Fu Shi
AU - Lee, Gi Ja
N1 - Publisher Copyright:
© 2021 Fu-Shi Quan and Gi-Ja Lee.
PY - 2021
Y1 - 2021
N2 - Hydrogen sulfide (H2S) plays an important role in mammals as a signaling molecule. Recently, abnormal H2S concentration has been associated with several pathophysiological states, such as diabetes mellitus, hypertension, Alzheimer's disease, and Parkinson's disease. As regulating H2S concentration can be a very prominent way of developing new drugs, many researchers have paid great attention to H2S research. To understand the role of H2S in pathophysiology and develop H2S-based therapies, it is necessary to measure the exact concentration of H2S within biological systems. But, H2S is volatile and can be easily oxidized. Besides, the active sites for several biological effects of H2S are inside the cell. Therefore, there is a need for the development of new methods for the accurate and reliable detection of H2S within live cells. This review provides a summary of recent developments in H2S detection methods for live cell analysis.
AB - Hydrogen sulfide (H2S) plays an important role in mammals as a signaling molecule. Recently, abnormal H2S concentration has been associated with several pathophysiological states, such as diabetes mellitus, hypertension, Alzheimer's disease, and Parkinson's disease. As regulating H2S concentration can be a very prominent way of developing new drugs, many researchers have paid great attention to H2S research. To understand the role of H2S in pathophysiology and develop H2S-based therapies, it is necessary to measure the exact concentration of H2S within biological systems. But, H2S is volatile and can be easily oxidized. Besides, the active sites for several biological effects of H2S are inside the cell. Therefore, there is a need for the development of new methods for the accurate and reliable detection of H2S within live cells. This review provides a summary of recent developments in H2S detection methods for live cell analysis.
UR - http://www.scopus.com/inward/record.url?scp=85114634232&partnerID=8YFLogxK
U2 - 10.1155/2021/5473965
DO - 10.1155/2021/5473965
M3 - Review article
C2 - 34497847
AN - SCOPUS:85114634232
VL - 2021
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
M1 - 5473965
ER -
