Anhydrous hydration of nitriles to amides using aldoximes as the water source

Jinwoo Lee; Min Kim; Sukbok Chang; Hee Yoon Lee

doi:10.1021/ol902309z

Anhydrous hydration of nitriles to amides using aldoximes as the water source

Jinwoo Lee
, Min Kim
, Sukbok Chang
, Hee Yoon Lee

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

[Chemical Equation Presented] Anhydrous hydrolysis of nitriles to amides was developed using acetaldoxime as the water source In the presence of Rh catalyst. Conversion of various nitriles to amides was performed under neutral and anhydrous conditions, and the reaction displays excellent compatibility with acid or base labile and hydrolytically labile functional groups.

Original language	English
Pages (from-to)	5598-5601
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	24
DOIs	https://doi.org/10.1021/ol902309z
Publication status	Published - 17 Dec 2009

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10.1021/ol902309z

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title = "Anhydrous hydration of nitriles to amides using aldoximes as the water source",

abstract = "[Chemical Equation Presented] Anhydrous hydrolysis of nitriles to amides was developed using acetaldoxime as the water source In the presence of Rh catalyst. Conversion of various nitriles to amides was performed under neutral and anhydrous conditions, and the reaction displays excellent compatibility with acid or base labile and hydrolytically labile functional groups.",

author = "Jinwoo Lee and Min Kim and Sukbok Chang and Lee, \{Hee Yoon\}",

year = "2009",

month = dec,

day = "17",

doi = "10.1021/ol902309z",

language = "English",

volume = "11",

pages = "5598--5601",

journal = "Organic Letters",

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T1 - Anhydrous hydration of nitriles to amides using aldoximes as the water source

AU - Lee, Jinwoo

AU - Kim, Min

AU - Chang, Sukbok

AU - Lee, Hee Yoon

PY - 2009/12/17

Y1 - 2009/12/17

N2 - [Chemical Equation Presented] Anhydrous hydrolysis of nitriles to amides was developed using acetaldoxime as the water source In the presence of Rh catalyst. Conversion of various nitriles to amides was performed under neutral and anhydrous conditions, and the reaction displays excellent compatibility with acid or base labile and hydrolytically labile functional groups.

AB - [Chemical Equation Presented] Anhydrous hydrolysis of nitriles to amides was developed using acetaldoxime as the water source In the presence of Rh catalyst. Conversion of various nitriles to amides was performed under neutral and anhydrous conditions, and the reaction displays excellent compatibility with acid or base labile and hydrolytically labile functional groups.

UR - https://www.scopus.com/pages/publications/72849113087

U2 - 10.1021/ol902309z

DO - 10.1021/ol902309z

M3 - Article

AN - SCOPUS:72849113087

SN - 1523-7060

VL - 11

SP - 5598

EP - 5601

JO - Organic Letters

JF - Organic Letters

IS - 24

ER -

Anhydrous hydration of nitriles to amides using aldoximes as the water source

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