Anti-allergic effect of Petasites japonicus fermented with lactic acid bacteria in mice

Eun Ah Bae; Hien Trung Trinh; Yun Ah Jang; Hyung Kwon Yun; Seong Sig Hong; Dong Hyun Kim

doi:10.1080/09540100902974019

Anti-allergic effect of Petasites japonicus fermented with lactic acid bacteria in mice

Eun Ah Bae
, Hien Trung Trinh
, Yun Ah Jang
, Hyung Kwon Yun
, Seong Sig Hong
, Dong Hyun Kim

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Petasites japonicus (PJ, family Asteraceae) was fermented with lactic acid bacteria (LAB), Bifidobacterium breve (BB) or Lactobacillus acidophilus (LA), and its allergic effect was investigated. LAB-fermented PJs more potently inhibited IgE-antigen-stimulated degranulation of RBL-2H3 cells than non-fermented PJ, with BB-fermented PJ more potent than LA-fermented PJ. Fermented PJ more potently inhibited TNF-α and IL-4 cytokine expression and transcription factor NF-kB activation in IgE-induced RBL-2H3 cells. PJ and BB-fermented PJ also inhibited IgE-antigen-induced passive cutaneous anaphylaxis (PCA) reactions as well as compound 48/80-induced scratching behaviours in mice, with fermented PJ more potent than non-fermented PJ. These findings suggest that PJ may show anti-allergic effects by inhibiting degranulation, and TNF-a and IL-4 expression and its anti-allergic effects can be enhanced by LAB fermentation.

Original language	English
Pages (from-to)	155-164
Number of pages	10
Journal	Food and Agricultural Immunology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1080/09540100902974019
Publication status	Published - Jun 2009

Bibliographical note

Funding Information:
This work was supported by a Grant from the Korean Rural Development Administration (2006).

Keywords

Fermentation
Itching
Lactic acid bacteria
Passive cutaneous anaphylaxis reaction
Petasites japonicus

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10.1080/09540100902974019

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@article{fd224f5c12e94b19aecdd10c47bc5071,

title = "Anti-allergic effect of Petasites japonicus fermented with lactic acid bacteria in mice",

abstract = "Petasites japonicus (PJ, family Asteraceae) was fermented with lactic acid bacteria (LAB), Bifidobacterium breve (BB) or Lactobacillus acidophilus (LA), and its allergic effect was investigated. LAB-fermented PJs more potently inhibited IgE-antigen-stimulated degranulation of RBL-2H3 cells than non-fermented PJ, with BB-fermented PJ more potent than LA-fermented PJ. Fermented PJ more potently inhibited TNF-α and IL-4 cytokine expression and transcription factor NF-kB activation in IgE-induced RBL-2H3 cells. PJ and BB-fermented PJ also inhibited IgE-antigen-induced passive cutaneous anaphylaxis (PCA) reactions as well as compound 48/80-induced scratching behaviours in mice, with fermented PJ more potent than non-fermented PJ. These findings suggest that PJ may show anti-allergic effects by inhibiting degranulation, and TNF-a and IL-4 expression and its anti-allergic effects can be enhanced by LAB fermentation.",

keywords = "Fermentation, Itching, Lactic acid bacteria, Passive cutaneous anaphylaxis reaction, Petasites japonicus",

author = "Bae, \{Eun Ah\} and Trinh, \{Hien Trung\} and Jang, \{Yun Ah\} and Yun, \{Hyung Kwon\} and Hong, \{Seong Sig\} and Kim, \{Dong Hyun\}",

note = "Funding Information: This work was supported by a Grant from the Korean Rural Development Administration (2006).",

year = "2009",

month = jun,

doi = "10.1080/09540100902974019",

language = "English",

volume = "20",

pages = "155--164",

journal = "Food and Agricultural Immunology",

issn = "0954-0105",

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T1 - Anti-allergic effect of Petasites japonicus fermented with lactic acid bacteria in mice

AU - Bae, Eun Ah

AU - Trinh, Hien Trung

AU - Jang, Yun Ah

AU - Yun, Hyung Kwon

AU - Hong, Seong Sig

AU - Kim, Dong Hyun

N1 - Funding Information: This work was supported by a Grant from the Korean Rural Development Administration (2006).

PY - 2009/6

Y1 - 2009/6

N2 - Petasites japonicus (PJ, family Asteraceae) was fermented with lactic acid bacteria (LAB), Bifidobacterium breve (BB) or Lactobacillus acidophilus (LA), and its allergic effect was investigated. LAB-fermented PJs more potently inhibited IgE-antigen-stimulated degranulation of RBL-2H3 cells than non-fermented PJ, with BB-fermented PJ more potent than LA-fermented PJ. Fermented PJ more potently inhibited TNF-α and IL-4 cytokine expression and transcription factor NF-kB activation in IgE-induced RBL-2H3 cells. PJ and BB-fermented PJ also inhibited IgE-antigen-induced passive cutaneous anaphylaxis (PCA) reactions as well as compound 48/80-induced scratching behaviours in mice, with fermented PJ more potent than non-fermented PJ. These findings suggest that PJ may show anti-allergic effects by inhibiting degranulation, and TNF-a and IL-4 expression and its anti-allergic effects can be enhanced by LAB fermentation.

AB - Petasites japonicus (PJ, family Asteraceae) was fermented with lactic acid bacteria (LAB), Bifidobacterium breve (BB) or Lactobacillus acidophilus (LA), and its allergic effect was investigated. LAB-fermented PJs more potently inhibited IgE-antigen-stimulated degranulation of RBL-2H3 cells than non-fermented PJ, with BB-fermented PJ more potent than LA-fermented PJ. Fermented PJ more potently inhibited TNF-α and IL-4 cytokine expression and transcription factor NF-kB activation in IgE-induced RBL-2H3 cells. PJ and BB-fermented PJ also inhibited IgE-antigen-induced passive cutaneous anaphylaxis (PCA) reactions as well as compound 48/80-induced scratching behaviours in mice, with fermented PJ more potent than non-fermented PJ. These findings suggest that PJ may show anti-allergic effects by inhibiting degranulation, and TNF-a and IL-4 expression and its anti-allergic effects can be enhanced by LAB fermentation.

KW - Fermentation

KW - Itching

KW - Lactic acid bacteria

KW - Passive cutaneous anaphylaxis reaction

KW - Petasites japonicus

UR - https://www.scopus.com/pages/publications/70449440394

U2 - 10.1080/09540100902974019

DO - 10.1080/09540100902974019

M3 - Article

AN - SCOPUS:70449440394

SN - 0954-0105

VL - 20

SP - 155

EP - 164

JO - Food and Agricultural Immunology

JF - Food and Agricultural Immunology

IS - 2

ER -

Anti-allergic effect of Petasites japonicus fermented with lactic acid bacteria in mice

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Keywords

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