Anti-fibrotic effects of Kyungheechunggan-tang on activated hepatic stellate cells and rat liver

Hea Jung Yan; Soo Young Kwon; Ki Suk Kim; Hyeon soo Jeong; Yoomi Kim; Won Seok Chung; Jang Hoon Lee; Hyeung Jin Jang

doi:10.1007/s13273-014-0046-3

Anti-fibrotic effects of Kyungheechunggan-tang on activated hepatic stellate cells and rat liver

Hea Jung Yan, Soo Young Kwon, Ki Suk Kim, Hyeon soo Jeong, Yoomi Kim, Won Seok Chung, Jang Hoon Lee, Hyeung Jin Jang

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Kyungheechunggan-tang (KHCGT), a mixture of 9 herbal aqueous extracts, is known in traditional Korean hepatoprotective medicine. To investigate the anti-fibrotic effect of KHCGT and its herbal ingredients, hepatic stellate cells (HSC) were activated by transforming growth factor-β (TGF-β), and the mRNA and protein expression levels of collagen type-1 (collagen-1) and α-smooth muscle actin (α-SMA) were measured. KHCGT and its 7 herbal ingredient among 9 herbal ingredients had an anti-fibrotic effect on activated HSC. Among the herbal samples, Artemisia capillaris, Salvia miltiorrhiza, Curcuma wenyujin showed the highest down-regulatory effect on α-SMA and collagen-1 mRNA expression. The liver tissues of dimethylnitrosamine (DMN)-induced rats were isolated to investigate the anti-fibrotic effect of KHCGT. This study provides understandings the effect of KHCGT and its ingredient herbal medicines on the activated HSC, and suggests herbal ingredient that plays a major role in anti-fibrotic effect of the KHCGT.

Original language	English
Pages (from-to)	411-421
Number of pages	11
Journal	Molecular and Cellular Toxicology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1007/s13273-014-0046-3
Publication status	Published - Dec 2014

Bibliographical note

Publisher Copyright:
© 2014, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media Dordrecht.

Keywords

Anti-fibrosis
Collagen type-1 (collagen-1)
Kyungheechunggan-tang (KHCGT)
α-smooth muscle actin (α-SMA)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13273-014-0046-3

Cite this

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title = "Anti-fibrotic effects of Kyungheechunggan-tang on activated hepatic stellate cells and rat liver",

abstract = "Kyungheechunggan-tang (KHCGT), a mixture of 9 herbal aqueous extracts, is known in traditional Korean hepatoprotective medicine. To investigate the anti-fibrotic effect of KHCGT and its herbal ingredients, hepatic stellate cells (HSC) were activated by transforming growth factor-β (TGF-β), and the mRNA and protein expression levels of collagen type-1 (collagen-1) and α-smooth muscle actin (α-SMA) were measured. KHCGT and its 7 herbal ingredient among 9 herbal ingredients had an anti-fibrotic effect on activated HSC. Among the herbal samples, Artemisia capillaris, Salvia miltiorrhiza, Curcuma wenyujin showed the highest down-regulatory effect on α-SMA and collagen-1 mRNA expression. The liver tissues of dimethylnitrosamine (DMN)-induced rats were isolated to investigate the anti-fibrotic effect of KHCGT. This study provides understandings the effect of KHCGT and its ingredient herbal medicines on the activated HSC, and suggests herbal ingredient that plays a major role in anti-fibrotic effect of the KHCGT.",

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AU - Yan, Hea Jung

AU - Kwon, Soo Young

AU - Kim, Ki Suk

AU - Jeong, Hyeon soo

AU - Kim, Yoomi

AU - Chung, Won Seok

AU - Lee, Jang Hoon

AU - Jang, Hyeung Jin

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AB - Kyungheechunggan-tang (KHCGT), a mixture of 9 herbal aqueous extracts, is known in traditional Korean hepatoprotective medicine. To investigate the anti-fibrotic effect of KHCGT and its herbal ingredients, hepatic stellate cells (HSC) were activated by transforming growth factor-β (TGF-β), and the mRNA and protein expression levels of collagen type-1 (collagen-1) and α-smooth muscle actin (α-SMA) were measured. KHCGT and its 7 herbal ingredient among 9 herbal ingredients had an anti-fibrotic effect on activated HSC. Among the herbal samples, Artemisia capillaris, Salvia miltiorrhiza, Curcuma wenyujin showed the highest down-regulatory effect on α-SMA and collagen-1 mRNA expression. The liver tissues of dimethylnitrosamine (DMN)-induced rats were isolated to investigate the anti-fibrotic effect of KHCGT. This study provides understandings the effect of KHCGT and its ingredient herbal medicines on the activated HSC, and suggests herbal ingredient that plays a major role in anti-fibrotic effect of the KHCGT.

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Anti-fibrotic effects of Kyungheechunggan-tang on activated hepatic stellate cells and rat liver

Abstract

Bibliographical note

Keywords

UN SDGs

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