Anti-inflammatory effect of green tea petiole extracts in poly(I:C)–stimulated human epidermal keratinocytes and a human 3D skin equivalent

Nok Hyun Park; Il Hong Bae; Seonsoo Han; Minkee Kim; Sung Hoon Lee; Won Seok Park; Chang Seok Lee; Jae Sung Hwang

doi:10.1177/2058739219857576

Anti-inflammatory effect of green tea petiole extracts in poly(I:C)–stimulated human epidermal keratinocytes and a human 3D skin equivalent

Nok Hyun Park, Il Hong Bae, Seonsoo Han, Minkee Kim, Sung Hoon Lee, Won Seok Park, Chang Seok Lee, Jae Sung Hwang

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Abstract

Green tea is one of the most popular non-alcoholic beverage crops worldwide. Leaf extracts of the green tea, Camellia sinensis, are known to have natural anti-oxidant and anti-inflammatory effects. However, relatively few studies have focused on the biological activities of green tea petiole (GTP) (the stalk that attaches the leaf blade to the stem, currently considered waste material) compared with other parts of the tree, such as the leaf, root, and flower. Here, we report the first investigation of the anti-inflammatory effect of GTP extract against poly(I:C)–stimulated human keratinocytes (a model of skin inflammatory conditions) and EpiDerm (a three-dimensional skin equivalent). Our results reveal that GTP extract suppresses the induction of the messenger ribonucleic acids (mRNAs) encoding pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-α), Interleukin 1 beta (IL-1β), and Interleukin-8 (IL-8)) and matrix metalloproteinase-1 (MMP-1). These findings indicate that GTP extract could prove useful in protecting skin cells from inflammatory conditions and skin aging.

Original language	English
Journal	European Journal of Inflammation
Volume	17
DOIs	https://doi.org/10.1177/2058739219857576
Publication status	Published - 2019

Bibliographical note

Publisher Copyright:
© The Author(s) 2019.

Keywords

green tea petiole extract
inflammation
keratinocyte
toll-like receptor

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title = "Anti-inflammatory effect of green tea petiole extracts in poly(I:C)–stimulated human epidermal keratinocytes and a human 3D skin equivalent",

abstract = "Green tea is one of the most popular non-alcoholic beverage crops worldwide. Leaf extracts of the green tea, Camellia sinensis, are known to have natural anti-oxidant and anti-inflammatory effects. However, relatively few studies have focused on the biological activities of green tea petiole (GTP) (the stalk that attaches the leaf blade to the stem, currently considered waste material) compared with other parts of the tree, such as the leaf, root, and flower. Here, we report the first investigation of the anti-inflammatory effect of GTP extract against poly(I:C)–stimulated human keratinocytes (a model of skin inflammatory conditions) and EpiDerm (a three-dimensional skin equivalent). Our results reveal that GTP extract suppresses the induction of the messenger ribonucleic acids (mRNAs) encoding pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-α), Interleukin 1 beta (IL-1β), and Interleukin-8 (IL-8)) and matrix metalloproteinase-1 (MMP-1). These findings indicate that GTP extract could prove useful in protecting skin cells from inflammatory conditions and skin aging.",

keywords = "green tea petiole extract, inflammation, keratinocyte, toll-like receptor",

author = "Park, {Nok Hyun} and Bae, {Il Hong} and Seonsoo Han and Minkee Kim and Lee, {Sung Hoon} and Park, {Won Seok} and Lee, {Chang Seok} and Hwang, {Jae Sung}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2019.",

year = "2019",

doi = "10.1177/2058739219857576",

language = "English",

volume = "17",

journal = "European Journal of Inflammation",

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T1 - Anti-inflammatory effect of green tea petiole extracts in poly(I:C)–stimulated human epidermal keratinocytes and a human 3D skin equivalent

AU - Park, Nok Hyun

AU - Bae, Il Hong

AU - Han, Seonsoo

AU - Kim, Minkee

AU - Lee, Sung Hoon

AU - Park, Won Seok

AU - Lee, Chang Seok

AU - Hwang, Jae Sung

PY - 2019

Y1 - 2019

N2 - Green tea is one of the most popular non-alcoholic beverage crops worldwide. Leaf extracts of the green tea, Camellia sinensis, are known to have natural anti-oxidant and anti-inflammatory effects. However, relatively few studies have focused on the biological activities of green tea petiole (GTP) (the stalk that attaches the leaf blade to the stem, currently considered waste material) compared with other parts of the tree, such as the leaf, root, and flower. Here, we report the first investigation of the anti-inflammatory effect of GTP extract against poly(I:C)–stimulated human keratinocytes (a model of skin inflammatory conditions) and EpiDerm (a three-dimensional skin equivalent). Our results reveal that GTP extract suppresses the induction of the messenger ribonucleic acids (mRNAs) encoding pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-α), Interleukin 1 beta (IL-1β), and Interleukin-8 (IL-8)) and matrix metalloproteinase-1 (MMP-1). These findings indicate that GTP extract could prove useful in protecting skin cells from inflammatory conditions and skin aging.

AB - Green tea is one of the most popular non-alcoholic beverage crops worldwide. Leaf extracts of the green tea, Camellia sinensis, are known to have natural anti-oxidant and anti-inflammatory effects. However, relatively few studies have focused on the biological activities of green tea petiole (GTP) (the stalk that attaches the leaf blade to the stem, currently considered waste material) compared with other parts of the tree, such as the leaf, root, and flower. Here, we report the first investigation of the anti-inflammatory effect of GTP extract against poly(I:C)–stimulated human keratinocytes (a model of skin inflammatory conditions) and EpiDerm (a three-dimensional skin equivalent). Our results reveal that GTP extract suppresses the induction of the messenger ribonucleic acids (mRNAs) encoding pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-α), Interleukin 1 beta (IL-1β), and Interleukin-8 (IL-8)) and matrix metalloproteinase-1 (MMP-1). These findings indicate that GTP extract could prove useful in protecting skin cells from inflammatory conditions and skin aging.

KW - green tea petiole extract

KW - inflammation

KW - keratinocyte

KW - toll-like receptor

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DO - 10.1177/2058739219857576

M3 - Letter

AN - SCOPUS:85081401647

SN - 1721-727X

VL - 17

JO - European Journal of Inflammation

JF - European Journal of Inflammation

ER -

Anti-inflammatory effect of green tea petiole extracts in poly(I:C)–stimulated human epidermal keratinocytes and a human 3D skin equivalent

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Keywords

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