Anti-inflammatory effect of phytoncide in an animal model of gastrointestinal inflammation

Azra Memon, Bae Yong Kim, Se Eun Kim, Yuliya Pyao, Yeong Geun Lee, Se Chan Kang, Woon Kyu Lee

Research output: Contribution to journalArticlepeer-review


Background: Phytoncide is known to have antimicrobial and anti-inflammatory properties. Purpose: This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. Methods: We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. Result: In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited (p < 0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group (p < 0.05). Conclusions: Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent.

Original languageEnglish
Article number1895
Issue number7
Publication statusPublished - 1 Apr 2021


  • Anti-inflammation
  • Colitis
  • Gastritis
  • Phytoncide
  • Pinus koraiensis


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