Anti-ischemic effect of Aurantii Fructus on contractile dysfunction of ischemic and reperfused rat heart

Moonkyu Kang; Jong Hoon Kim; Chongwoon Cho; Hwan Suck Chung; Chang Woon Kang; Yangseok Kim; Minkyu Shin; Moochang Hong; Hyunsu Bae

doi:10.1016/j.jep.2007.01.007

Anti-ischemic effect of Aurantii Fructus on contractile dysfunction of ischemic and reperfused rat heart

Moonkyu Kang
, Jong Hoon Kim
, Chongwoon Cho
, Hwan Suck Chung
, Chang Woon Kang
, Yangseok Kim
, Minkyu Shin
, Moochang Hong
, Hyunsu Bae

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Aurantii Fructus (AF) is one of the most well-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in Korea. The anti-ischemic effects of AF on ischemia-induced isolated rat heart were investigated through analyses of changes in perfusion pressure, aortic flow, coronary flow, and cardiac output. The subjects in this study were divided into two groups: an ischemia-induced group without any treatment, and an ischemia-induced group with AF treatment. There were no significant differences in perfusion pressure, aortic flow, coronary flow, and cardiac output between them before ischemia was induced. The supply of oxygen and buffer was stopped for 10 min to induce ischemia in isolated rat hearts, and AF was administered during ischemia induction. AF treatment significantly prevented decreases in perfusion pressure, aortic flow, coronary flow, and cardiac output under ischemic conditions (p < 0.01). These results suggest that AF has distinct anti-ischemic effects through recovery of contractile dysfunction in ischemic heart.

Original language	English
Pages (from-to)	584-591
Number of pages	8
Journal	Journal of Ethnopharmacology
Volume	111
Issue number	3
DOIs	https://doi.org/10.1016/j.jep.2007.01.007
Publication status	Published - 22 May 2007

Bibliographical note

Funding Information:
This research was financially supported by a grant from the Ministry of Science and Technology of Korea (#2005-00198), a grant from the Korean Health 21 R&D Project, Ministry of Health & Welfare, Korea (A06-00044227), the Brain Korea 21 project in 2006 and research grant from Bio-Safety Research Institute, Chonbuk National University in 2006.

Keywords

Anti-ischemia effect
Aurantii Fructus
Traditional herbal medicine

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10.1016/j.jep.2007.01.007

Cite this

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title = "Anti-ischemic effect of Aurantii Fructus on contractile dysfunction of ischemic and reperfused rat heart",

abstract = "Aurantii Fructus (AF) is one of the most well-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in Korea. The anti-ischemic effects of AF on ischemia-induced isolated rat heart were investigated through analyses of changes in perfusion pressure, aortic flow, coronary flow, and cardiac output. The subjects in this study were divided into two groups: an ischemia-induced group without any treatment, and an ischemia-induced group with AF treatment. There were no significant differences in perfusion pressure, aortic flow, coronary flow, and cardiac output between them before ischemia was induced. The supply of oxygen and buffer was stopped for 10 min to induce ischemia in isolated rat hearts, and AF was administered during ischemia induction. AF treatment significantly prevented decreases in perfusion pressure, aortic flow, coronary flow, and cardiac output under ischemic conditions (p < 0.01). These results suggest that AF has distinct anti-ischemic effects through recovery of contractile dysfunction in ischemic heart.",

keywords = "Anti-ischemia effect, Aurantii Fructus, Traditional herbal medicine",

author = "Moonkyu Kang and Kim, \{Jong Hoon\} and Chongwoon Cho and Chung, \{Hwan Suck\} and Kang, \{Chang Woon\} and Yangseok Kim and Minkyu Shin and Moochang Hong and Hyunsu Bae",

note = "Funding Information: This research was financially supported by a grant from the Ministry of Science and Technology of Korea (\#2005-00198), a grant from the Korean Health 21 R\&D Project, Ministry of Health \& Welfare, Korea (A06-00044227), the Brain Korea 21 project in 2006 and research grant from Bio-Safety Research Institute, Chonbuk National University in 2006.",

year = "2007",

month = may,

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doi = "10.1016/j.jep.2007.01.007",

language = "English",

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pages = "584--591",

journal = "Journal of Ethnopharmacology",

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AU - Kang, Moonkyu

AU - Kim, Jong Hoon

AU - Cho, Chongwoon

AU - Chung, Hwan Suck

AU - Kang, Chang Woon

AU - Kim, Yangseok

AU - Shin, Minkyu

AU - Hong, Moochang

AU - Bae, Hyunsu

N1 - Funding Information: This research was financially supported by a grant from the Ministry of Science and Technology of Korea (#2005-00198), a grant from the Korean Health 21 R&D Project, Ministry of Health & Welfare, Korea (A06-00044227), the Brain Korea 21 project in 2006 and research grant from Bio-Safety Research Institute, Chonbuk National University in 2006.

PY - 2007/5/22

Y1 - 2007/5/22

N2 - Aurantii Fructus (AF) is one of the most well-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in Korea. The anti-ischemic effects of AF on ischemia-induced isolated rat heart were investigated through analyses of changes in perfusion pressure, aortic flow, coronary flow, and cardiac output. The subjects in this study were divided into two groups: an ischemia-induced group without any treatment, and an ischemia-induced group with AF treatment. There were no significant differences in perfusion pressure, aortic flow, coronary flow, and cardiac output between them before ischemia was induced. The supply of oxygen and buffer was stopped for 10 min to induce ischemia in isolated rat hearts, and AF was administered during ischemia induction. AF treatment significantly prevented decreases in perfusion pressure, aortic flow, coronary flow, and cardiac output under ischemic conditions (p < 0.01). These results suggest that AF has distinct anti-ischemic effects through recovery of contractile dysfunction in ischemic heart.

AB - Aurantii Fructus (AF) is one of the most well-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in Korea. The anti-ischemic effects of AF on ischemia-induced isolated rat heart were investigated through analyses of changes in perfusion pressure, aortic flow, coronary flow, and cardiac output. The subjects in this study were divided into two groups: an ischemia-induced group without any treatment, and an ischemia-induced group with AF treatment. There were no significant differences in perfusion pressure, aortic flow, coronary flow, and cardiac output between them before ischemia was induced. The supply of oxygen and buffer was stopped for 10 min to induce ischemia in isolated rat hearts, and AF was administered during ischemia induction. AF treatment significantly prevented decreases in perfusion pressure, aortic flow, coronary flow, and cardiac output under ischemic conditions (p < 0.01). These results suggest that AF has distinct anti-ischemic effects through recovery of contractile dysfunction in ischemic heart.

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KW - Traditional herbal medicine

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ER -

Anti-ischemic effect of Aurantii Fructus on contractile dysfunction of ischemic and reperfused rat heart

Abstract

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Keywords

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