Anti-obesity effect of 3,5-dicaffeoylquinic acid on high-fat diet mouse

Jin Yong Kang, Seon Kyeong Park, Jong Min Kim, Su Bin Park, Seul Ki Yoo, Hye Ju Han, Dae Ok Kim, Ho Jin Heo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

This study was performed to confirm the influence of chlorogenic acid (CGA) and 3,5-dicaffeyolquinic acid (3,5-diCQA) intake on problems caused by high-fat diet. CGA was more effective in suppressing weight gain than 3,5-diCQA. In contrast, 3,5-diCQA was more effective in improving glucose tolerance than CGA. In the biopsy, it was confirmed that CGA inhibited visceral fat and liver fat accumulation. 3,5-diCQA also inhibited visceral fat accumulation, but 3,5-diCQA increased liver fat accumulation. The liver fat accumulation induced oxidative stress, but 3,5-diCQA reduced oxidative damage through its antioxidant activity. The increased liver fat accumulation was because a 3,5-diCQA greatly increased Akt phosphorylation and decreased AMPK phosphorylation in the liver. Consequently, CGA was effective in alleviating the problems caused by high-fat diets, while maintaining normal balance. 3,5-diCQA also showed a positive effect on problems caused by high-fat diets, but it increased liver fat accumulation and thereby had negative consequences.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalKorean Journal of Food Science and Technology
Volume51
Issue number1
DOIs
Publication statusPublished - 2019

Keywords

  • 3,5-dicaffeoylquinic acid
  • Chlorogenic acid
  • Obesity
  • P-Akt
  • P-AMPK

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