Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice

Hyun Jung Park, Sun Young Lee, Minsook Ye, Bong Hee Han, Hyun Soo Shim, Daehyuk Jang, Insop Shim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Chitoglucan (CG) is a bioactive component obtained from Flammulina velutipes Sing, an edible mushroom, which is known to have an anti-obesity effect. However, its biological and hormonal activities in alleviating obesity through regulation of adipocyte-derived proteins have not been examined yet. Purpose: The present study aimed to investigate the anti-obesity effects of chitoglucan and its hormonal mechanisms in high-fat diet (HFD)-induced mice. Methods: The mice were fed either a normal diet (Normal group) or a high fat diet (HFD group) over 6 weeks. The HFD fed mice were administered with saline (HFD group), adipex (HFD + adipex group), chitoglucan 50, 150, or 300 mg/kg/day for 3 weeks (HFD + CG groups). The food consumption, body weight, fat contents, and the levels of serum leptin and resistin were assessed after treatment of chitoglucan. Results: the HFD produced a marked increase in body and fat weights after 6 weeks of feeding compared with the Normal group. Administration of chitoglucan for 3 weeks tended to reduce body weight and significantly decreased parametrical adipose tissues in HFD groups. The level of serum leptin in the HFD group was markedly higher than that in the Normal group, whereas the level of leptin in the chitoglucan treated groups was significantly decreased in comparison with the HFD group. In addition, the level of serum resistin in high-fat diet group tended to be more increased than Normal group. However, the serum resistin level was significantly reduced in HF diet groups after treatment with chitoglucan (50 mg/kg or 150 mg/kg). Conclusion: Collectively, these data suggest that chitoglucan from the Flammulina velutipes may be useful in the treatment of high diet-induced obesity and metabolic syndrome.

Original languageEnglish
Article number281
JournalInternational Journal of Environmental Research and Public Health
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 2023

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

Keywords

  • Flammulina velutipes
  • anti-obesity
  • chitoglucan
  • high fat induced mice
  • resistin
  • serum leptin

Fingerprint

Dive into the research topics of 'Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice'. Together they form a unique fingerprint.

Cite this