Anti-photoaging effects of canola meal extract on human dermal fibroblasts against UVB-induced oxidative stress

Eun Ha Park, Inil Lee, Gi Cheol Park, Seung Ju Lee, Kwan Joong Kim, Jisuk Yun, Dae Ok Kim

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Canola meal, a by-product of canola oil processing, is a source of bioactive compounds that show antioxidant and skin anti-aging effects through upcycling (i.e., creative reuse). Here we describe the antioxidant and skin anti-aging effects of canola meal extract (CME) obtained by upcycling canola meal. The antioxidant capacity of CME is due in part to its antioxidative phenolics. Seven phenolics, including sinapine and sinapic acid, in CME were identified using ultra-high-performance liquid chromatography–Orbitrap mass spectrometry. Addition of CME (1000 μg/mL) to human dermal fibroblast neonatal cells significantly (p < 0.05) reduced matrix metalloproteinase-12 production and increased pro-collagen Ι alpha 1 content in response to ultraviolet B-induced oxidative stress compared with cells without CME. These results suggest that CME can serve as a functional food ingredient with antioxidant capacity and anti-aging effects on the skin.

Original languageEnglish
Pages (from-to)667-676
Number of pages10
JournalFood Science and Biotechnology
Volume33
Issue number3
DOIs
Publication statusPublished - Feb 2024

Bibliographical note

Publisher Copyright:
© 2023, The Korean Society of Food Science and Technology.

Keywords

  • Collagen
  • Matrix metalloproteinase
  • Sinapic acid
  • Sinapine
  • Ultraviolet B
  • Upcycling

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