Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells

Min Ai Lee; Won Kyung Kim; Hyen Joo Park; Sam Sik Kang; Sang Kook Lee

doi:10.1016/j.bmcl.2013.08.065

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells

Min Ai Lee, Won Kyung Kim, Hyen Joo Park, Sam Sik Kang, Sang Kook Lee

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Based on the Wnt inhibitors as potential targets in the development of anticancer agents, natural compounds were evaluated for β-catenin-mediated transcriptional activity. A natural lignan hydnocarpin isolated from Lonicera japonica was considered a potential inhibitor for Wnt/β-catenin signalings. The anti-proliferative activity of hydnocarpin was also found to be associated with the suppression of Wnt/β-catenin-mediated signaling pathway in human colon cancer cells. These data suggest that hydnocarpin might be a novel Wnt inhibitor and has a potential of signaling regulator in β-catenin-mediated signaling pathways.

Original language	English
Pages (from-to)	5511-5514
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	20
DOIs	https://doi.org/10.1016/j.bmcl.2013.08.065
Publication status	Published - 15 Oct 2013

Keywords

Anti-proliferation
Axin turnover
Colon cancer cells
Hydnocarpin
Wnt/beta-catenin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2013.08.065

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title = "Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells",

abstract = "Based on the Wnt inhibitors as potential targets in the development of anticancer agents, natural compounds were evaluated for β-catenin-mediated transcriptional activity. A natural lignan hydnocarpin isolated from Lonicera japonica was considered a potential inhibitor for Wnt/β-catenin signalings. The anti-proliferative activity of hydnocarpin was also found to be associated with the suppression of Wnt/β-catenin-mediated signaling pathway in human colon cancer cells. These data suggest that hydnocarpin might be a novel Wnt inhibitor and has a potential of signaling regulator in β-catenin-mediated signaling pathways.",

keywords = "Anti-proliferation, Axin turnover, Colon cancer cells, Hydnocarpin, Wnt/beta-catenin",

author = "Lee, {Min Ai} and Kim, {Won Kyung} and Park, {Hyen Joo} and Kang, {Sam Sik} and Lee, {Sang Kook}",

year = "2013",

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doi = "10.1016/j.bmcl.2013.08.065",

language = "English",

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AU - Lee, Min Ai

AU - Kim, Won Kyung

AU - Park, Hyen Joo

AU - Kang, Sam Sik

AU - Lee, Sang Kook

PY - 2013/10/15

Y1 - 2013/10/15

N2 - Based on the Wnt inhibitors as potential targets in the development of anticancer agents, natural compounds were evaluated for β-catenin-mediated transcriptional activity. A natural lignan hydnocarpin isolated from Lonicera japonica was considered a potential inhibitor for Wnt/β-catenin signalings. The anti-proliferative activity of hydnocarpin was also found to be associated with the suppression of Wnt/β-catenin-mediated signaling pathway in human colon cancer cells. These data suggest that hydnocarpin might be a novel Wnt inhibitor and has a potential of signaling regulator in β-catenin-mediated signaling pathways.

AB - Based on the Wnt inhibitors as potential targets in the development of anticancer agents, natural compounds were evaluated for β-catenin-mediated transcriptional activity. A natural lignan hydnocarpin isolated from Lonicera japonica was considered a potential inhibitor for Wnt/β-catenin signalings. The anti-proliferative activity of hydnocarpin was also found to be associated with the suppression of Wnt/β-catenin-mediated signaling pathway in human colon cancer cells. These data suggest that hydnocarpin might be a novel Wnt inhibitor and has a potential of signaling regulator in β-catenin-mediated signaling pathways.

KW - Anti-proliferation

KW - Axin turnover

KW - Colon cancer cells

KW - Hydnocarpin

KW - Wnt/beta-catenin

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AN - SCOPUS:84884288123

SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells

Abstract

Keywords

UN SDGs

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