Antidepressant-like effects of β-caryophyllene on restraint plus stress-induced depression

Eun Sang Hwang, Hyun Bum Kim, Seok Lee, Min Jeong Kim, Kwan Joong Kim, Gaeul Han, Se Young Han, Eun A. Lee, Jeong Hee Yoon, Dae Ok Kim, Sungho Maeng, Ji Ho Park

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Chronic stress is depressogenic by altering neurotrophic and neuroinflammatory environments of the organism. The endocannabinoid system controls cognitive and emotional responses related with stress through the interaction with endocannabinoid receptors. β-Caryophyllene (BCP) is a CB2 agonist that exhibited anti-inflammatory, analgesic effects but minimal psychoactive effects. To test if BCP exhibits antidepressant-like action, animals were chronically restrained with additional stressors for 28 days, and BCP (25, 50, 100 mg/kg) was intraperitoneally injected once a day during the stress inflicting period. Then despair related behaviors and hippocampal expression of neurotrophic, inflammatory and cannabinoid receptor levels were measured. To test the effect of BCP on long-term depression, field potentials were measured during the application of lipopolysaccharide and low frequency stimulation. In the tail suspension test and forced swim test, chronic stress-induced despair behaviors were reduced by BCP. Also BCP improved the stress-related changes in the hippocampal expression of COX-2, BDNF, and CB2 receptor expression. In organotypic hippocampal slices, BCP reduced the lipopolysaccharide-induced intensification of the long-term depression. In conclusion, BCP improved chronic stress related behavioral and biochemical changes. These results suggest that BCP may be effective in treating depression and stress related mental illnesses.

Original languageEnglish
Article number112439
JournalBehavioural Brain Research
Volume380
DOIs
Publication statusPublished - 17 Feb 2020

Keywords

  • Cannabinoid 2 receptor
  • Depression
  • Restraint-stress
  • β-Caryophyllene

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