TY - JOUR
T1 - Antidiabetic Effect of Fermented Mesembryanthemum crystallinum L. in db/db Mice Involves Regulation of PI3K-Akt Pathway
AU - Kim, Hye Lin
AU - Jung, Yunu
AU - Kim, Hyo In
AU - Sung, Nak Yun
AU - Kim, Min Jee
AU - Han, In Jun
AU - Kim, Geon
AU - Nho, Eun Yeong
AU - Park, Sang Yun
AU - Han, Yohan
AU - Jung, Ji Hoon
AU - Kim, Dong Sub
AU - Park, Jinbong
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/8
Y1 - 2023/8
N2 - Type 2 diabetes (T2D) is a serious health issue with increasing incidences worldwide. However, current medications have limitations due to side effects such as decreased appetite, stomach pain, diarrhea, and extreme tiredness. Here, we report the effect of fermented ice plant (FMC) in the T2M mouse model of db/db mice. FMC showed a greater inhibition of lipid accumulation compared to unfermented ice plant extract. Two-week oral administration with FMC inhibited body weight gain, lowered fasting blood glucose, and improved glucose tolerance. Serum parameters related to T2D including insulin, glycosylated hemoglobin, adiponectin, and cholesterols were improved as well. Histological analysis confirmed the protective effect of FMC on pancreas and liver destruction. FMC treatment significantly increased the expression and phosphorylation of IRS-1, PI3K, and AKT. Additionally, AMP-activated protein kinase phosphorylation and nuclear factor erythroid 2–related factor 2 were also increased in the liver tissues of db/db mice treated with FMC. Overall, our results indicate the anti-diabetic effect of FMC; therefore, we suggest that FMC may be useful as a therapeutic agent for T2D.
AB - Type 2 diabetes (T2D) is a serious health issue with increasing incidences worldwide. However, current medications have limitations due to side effects such as decreased appetite, stomach pain, diarrhea, and extreme tiredness. Here, we report the effect of fermented ice plant (FMC) in the T2M mouse model of db/db mice. FMC showed a greater inhibition of lipid accumulation compared to unfermented ice plant extract. Two-week oral administration with FMC inhibited body weight gain, lowered fasting blood glucose, and improved glucose tolerance. Serum parameters related to T2D including insulin, glycosylated hemoglobin, adiponectin, and cholesterols were improved as well. Histological analysis confirmed the protective effect of FMC on pancreas and liver destruction. FMC treatment significantly increased the expression and phosphorylation of IRS-1, PI3K, and AKT. Additionally, AMP-activated protein kinase phosphorylation and nuclear factor erythroid 2–related factor 2 were also increased in the liver tissues of db/db mice treated with FMC. Overall, our results indicate the anti-diabetic effect of FMC; therefore, we suggest that FMC may be useful as a therapeutic agent for T2D.
KW - AMP-activated protein kinase
KW - Mesembryanthemum crystallinumL
KW - fermented ice plant
KW - insulin receptor substrate 1
KW - nuclear factor erythroid 2–related factor 2
KW - phosphoinositide 3-kinase
KW - protein kinase B
KW - type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85168726300&partnerID=8YFLogxK
U2 - 10.3390/cimb45080405
DO - 10.3390/cimb45080405
M3 - Article
C2 - 37623224
AN - SCOPUS:85168726300
SN - 1467-3037
VL - 45
SP - 6415
EP - 6431
JO - Current Issues in Molecular Biology
JF - Current Issues in Molecular Biology
IS - 8
ER -
