TY - JOUR
T1 - Antihyperlipidemic and antioxidant effects of the mixture of ginseng radix and crataegi fructus
T2 - Experimental study and preliminary clinical results
AU - Ko, Chang Nam
AU - Park, Seong Uk
AU - Chang, Gyu Tae
AU - Jung, Woo Sang
AU - Moon, Sang Kwan
AU - Park, Jung Mi
AU - Cho, Ki Ho
PY - 2011/6
Y1 - 2011/6
N2 - The mixture of Ginseng Radix and Crataegi Fructus (Gen-CF) was developed to increase the pharmacological effect of ginseng in the treatment of hypercholesterolemia and prevention of cardiovascular disease. This study evaluated the effects of Gen-CF on serum lipids of hypercholesterolemic rats in vivo, as well as its antioxidant activities in vitro, and explored its clinical effects on patients with hypercholesterolemia. In vitro, Gen-CF displayed 1,1-diphenyl-2-picrylhydrasyl and superoxide radical scavenging activities, and inhibited hemolysis induced by 2,2'-azobis-2-amidinopropane dihydrochloride in a dose-dependent manner. In vivo, Gen-CF significantly inhibited the increases of total cholesterol, low-density lipoprotein cholesterol and triglyceride in high cholesterol-diet and Triton WR-1339 models. It also significantly inhibited the decrease of high-density lipoprotein cholesterol in these models. In the clinical trial, Gen-CF significantly lowered total cholesterol, low-density lipoprotein cholesterol, triglyceride, total lipid and phospholipid, with no adverse events, including hepatic or renal toxicity. The data suggest that Gen-CF has the potential to treat hypercholesterolemia and prevent cardiovascular disease.
AB - The mixture of Ginseng Radix and Crataegi Fructus (Gen-CF) was developed to increase the pharmacological effect of ginseng in the treatment of hypercholesterolemia and prevention of cardiovascular disease. This study evaluated the effects of Gen-CF on serum lipids of hypercholesterolemic rats in vivo, as well as its antioxidant activities in vitro, and explored its clinical effects on patients with hypercholesterolemia. In vitro, Gen-CF displayed 1,1-diphenyl-2-picrylhydrasyl and superoxide radical scavenging activities, and inhibited hemolysis induced by 2,2'-azobis-2-amidinopropane dihydrochloride in a dose-dependent manner. In vivo, Gen-CF significantly inhibited the increases of total cholesterol, low-density lipoprotein cholesterol and triglyceride in high cholesterol-diet and Triton WR-1339 models. It also significantly inhibited the decrease of high-density lipoprotein cholesterol in these models. In the clinical trial, Gen-CF significantly lowered total cholesterol, low-density lipoprotein cholesterol, triglyceride, total lipid and phospholipid, with no adverse events, including hepatic or renal toxicity. The data suggest that Gen-CF has the potential to treat hypercholesterolemia and prevent cardiovascular disease.
KW - Antioxidants
KW - Cardiovascular diseases
KW - Hypercholesterolemia
KW - Panax ginseng
UR - http://www.scopus.com/inward/record.url?scp=79959865557&partnerID=8YFLogxK
U2 - 10.5142/jgr.2011.35.2.162
DO - 10.5142/jgr.2011.35.2.162
M3 - Article
C2 - 23717058
AN - SCOPUS:79959865557
SN - 1226-8453
VL - 35
SP - 162
EP - 169
JO - Journal of Ginseng Research
JF - Journal of Ginseng Research
IS - 2
ER -