Antiinflammatory effects of Epimedium brevicornum water extract on lipopolysaccharide-activated RAW264.7 macrophages

Sang Suk Yuk; Eun Mee Lim; Ji Young Lee; Young Jong Lee; Yoon Sang Kim; Tae Hee Lee; Seong Kyu Park; Hyunsu Bae; Hyung Min Kim; Seong Gyu Ko; Myung Sook Oh; Wansu Park

doi:10.1002/ptr.3161

Antiinflammatory effects of Epimedium brevicornum water extract on lipopolysaccharide-activated RAW264.7 macrophages

Sang Suk Yuk, Eun Mee Lim, Ji Young Lee, Young Jong Lee, Yoon Sang Kim, Tae Hee Lee, Seong Kyu Park, Hyunsu Bae, Hyung Min Kim, Seong Gyu Ko, Myung Sook Oh, Wansu Park

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Epimedium brevicornum Maxim (Berberidaceae) possesses estrogenic properties. It is one of the most widespread herbal remedies used in Oriental medicine. The present study investigated the effects of Epimedium brevicornum water extract (EB) on proinflammatory mediators secreted from lipopolysaccharide (LPS)-induced RAW264.7 macrophages. EB significantly inhibited the production of nitric oxide (NO), interleukin (IL)-3, IL-10, IL-12p40, interferon-inducible protein-10, keratinocyte-derived chemokine, vascular endothelial growth factor, monocyte chemotactic protein-1 and granulocyte macrophage-colony stimulating factor in LPS-induced RAW264.7 cells at concentrations of 25, 50, 100 and 200 μg/mL (p < 0.05). These results suggest that EB has antiinflammatory activity related to its inhibition of NO, cytokine, chemokine and growth factor production in macrophages.

Original language	English
Pages (from-to)	1781-1787
Number of pages	7
Journal	Phytotherapy Research
Volume	24
Issue number	12
DOIs	https://doi.org/10.1002/ptr.3161
Publication status	Published - Dec 2010

Keywords

Berberidaceae
Epimedium brevicornum
antiinflammatory
cytokine
macrophage
nitric oxide

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title = "Antiinflammatory effects of Epimedium brevicornum water extract on lipopolysaccharide-activated RAW264.7 macrophages",

abstract = "Epimedium brevicornum Maxim (Berberidaceae) possesses estrogenic properties. It is one of the most widespread herbal remedies used in Oriental medicine. The present study investigated the effects of Epimedium brevicornum water extract (EB) on proinflammatory mediators secreted from lipopolysaccharide (LPS)-induced RAW264.7 macrophages. EB significantly inhibited the production of nitric oxide (NO), interleukin (IL)-3, IL-10, IL-12p40, interferon-inducible protein-10, keratinocyte-derived chemokine, vascular endothelial growth factor, monocyte chemotactic protein-1 and granulocyte macrophage-colony stimulating factor in LPS-induced RAW264.7 cells at concentrations of 25, 50, 100 and 200 μg/mL (p < 0.05). These results suggest that EB has antiinflammatory activity related to its inhibition of NO, cytokine, chemokine and growth factor production in macrophages.",

keywords = "Berberidaceae, Epimedium brevicornum, antiinflammatory, cytokine, macrophage, nitric oxide",

author = "Yuk, {Sang Suk} and Lim, {Eun Mee} and Lee, {Ji Young} and Lee, {Young Jong} and Kim, {Yoon Sang} and Lee, {Tae Hee} and Park, {Seong Kyu} and Hyunsu Bae and Kim, {Hyung Min} and Ko, {Seong Gyu} and Oh, {Myung Sook} and Wansu Park",

year = "2010",

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language = "English",

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AU - Lee, Ji Young

AU - Lee, Young Jong

AU - Kim, Yoon Sang

AU - Lee, Tae Hee

AU - Park, Seong Kyu

AU - Bae, Hyunsu

AU - Kim, Hyung Min

AU - Ko, Seong Gyu

AU - Oh, Myung Sook

AU - Park, Wansu

PY - 2010/12

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AB - Epimedium brevicornum Maxim (Berberidaceae) possesses estrogenic properties. It is one of the most widespread herbal remedies used in Oriental medicine. The present study investigated the effects of Epimedium brevicornum water extract (EB) on proinflammatory mediators secreted from lipopolysaccharide (LPS)-induced RAW264.7 macrophages. EB significantly inhibited the production of nitric oxide (NO), interleukin (IL)-3, IL-10, IL-12p40, interferon-inducible protein-10, keratinocyte-derived chemokine, vascular endothelial growth factor, monocyte chemotactic protein-1 and granulocyte macrophage-colony stimulating factor in LPS-induced RAW264.7 cells at concentrations of 25, 50, 100 and 200 μg/mL (p < 0.05). These results suggest that EB has antiinflammatory activity related to its inhibition of NO, cytokine, chemokine and growth factor production in macrophages.

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KW - cytokine

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KW - nitric oxide

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Antiinflammatory effects of Epimedium brevicornum water extract on lipopolysaccharide-activated RAW264.7 macrophages

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Keywords

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