Aqueous solubilization of paclitaxel using hydrotropic polymer micelle

Hyun Su Min; Hong Jae Lee; Sang Cheon Lee; Kyoung Hoon Kang; Jaehwi Lee; Kinam Park; Kang Moo Huh

doi:10.4028/0-87849-436-7.421

Aqueous solubilization of paclitaxel using hydrotropic polymer micelle

Hyun Su Min, Hong Jae Lee, Sang Cheon Lee, Kyoung Hoon Kang, Jaehwi Lee, Kinam Park, Kang Moo Huh

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Hydrotropic block copolymers, consisting of a hydrophilic poly(ethylene glycol) (PEG) block and a hydrotropic polymer, poly(2-(4-(vinyl benzyloxy)-N,N-diethylnicotinamide)) [P(VBODENA)], block, were synthesized by atom transfer radical polymerization (ATRP) for aqueous solubilization of paclitaxel, a representative poorly water-soluble drug. These polymers showed an excellent solubilizing effect for paclitaxel in aqueous media in comparison with the corresponding hydrotropic agent and a control micelle (PEG-PLA) and such effect was significantly dependent on the polymer concentration and composition. Paclitaxel could be solubilized into polymer micelles in aqueous media without use of an organic solvent. Due to their promising properties such as micellar characteristics and hydrotropic solubilization, the hydrotropic polymer micelle system can be useful for formulation of paclitaxel and other poorly soluble drugs.

Original language	English
Pages (from-to)	421-424
Number of pages	4
Journal	Key Engineering Materials
Volume	342-343
DOIs	https://doi.org/10.4028/0-87849-436-7.421
Publication status	Published - 2007

Keywords

Aqueous stabilization
Drug loading
Hydrotropic agent
Paclitaxel
Polymer micelle

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title = "Aqueous solubilization of paclitaxel using hydrotropic polymer micelle",

abstract = "Hydrotropic block copolymers, consisting of a hydrophilic poly(ethylene glycol) (PEG) block and a hydrotropic polymer, poly(2-(4-(vinyl benzyloxy)-N,N-diethylnicotinamide)) [P(VBODENA)], block, were synthesized by atom transfer radical polymerization (ATRP) for aqueous solubilization of paclitaxel, a representative poorly water-soluble drug. These polymers showed an excellent solubilizing effect for paclitaxel in aqueous media in comparison with the corresponding hydrotropic agent and a control micelle (PEG-PLA) and such effect was significantly dependent on the polymer concentration and composition. Paclitaxel could be solubilized into polymer micelles in aqueous media without use of an organic solvent. Due to their promising properties such as micellar characteristics and hydrotropic solubilization, the hydrotropic polymer micelle system can be useful for formulation of paclitaxel and other poorly soluble drugs.",

keywords = "Aqueous stabilization, Drug loading, Hydrotropic agent, Paclitaxel, Polymer micelle",

author = "Min, {Hyun Su} and Lee, {Hong Jae} and Lee, {Sang Cheon} and Kang, {Kyoung Hoon} and Jaehwi Lee and Kinam Park and Huh, {Kang Moo}",

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doi = "10.4028/0-87849-436-7.421",

language = "English",

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journal = "Key Engineering Materials",

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T1 - Aqueous solubilization of paclitaxel using hydrotropic polymer micelle

AU - Min, Hyun Su

AU - Lee, Hong Jae

AU - Lee, Sang Cheon

AU - Kang, Kyoung Hoon

AU - Lee, Jaehwi

AU - Park, Kinam

AU - Huh, Kang Moo

PY - 2007

Y1 - 2007

N2 - Hydrotropic block copolymers, consisting of a hydrophilic poly(ethylene glycol) (PEG) block and a hydrotropic polymer, poly(2-(4-(vinyl benzyloxy)-N,N-diethylnicotinamide)) [P(VBODENA)], block, were synthesized by atom transfer radical polymerization (ATRP) for aqueous solubilization of paclitaxel, a representative poorly water-soluble drug. These polymers showed an excellent solubilizing effect for paclitaxel in aqueous media in comparison with the corresponding hydrotropic agent and a control micelle (PEG-PLA) and such effect was significantly dependent on the polymer concentration and composition. Paclitaxel could be solubilized into polymer micelles in aqueous media without use of an organic solvent. Due to their promising properties such as micellar characteristics and hydrotropic solubilization, the hydrotropic polymer micelle system can be useful for formulation of paclitaxel and other poorly soluble drugs.

AB - Hydrotropic block copolymers, consisting of a hydrophilic poly(ethylene glycol) (PEG) block and a hydrotropic polymer, poly(2-(4-(vinyl benzyloxy)-N,N-diethylnicotinamide)) [P(VBODENA)], block, were synthesized by atom transfer radical polymerization (ATRP) for aqueous solubilization of paclitaxel, a representative poorly water-soluble drug. These polymers showed an excellent solubilizing effect for paclitaxel in aqueous media in comparison with the corresponding hydrotropic agent and a control micelle (PEG-PLA) and such effect was significantly dependent on the polymer concentration and composition. Paclitaxel could be solubilized into polymer micelles in aqueous media without use of an organic solvent. Due to their promising properties such as micellar characteristics and hydrotropic solubilization, the hydrotropic polymer micelle system can be useful for formulation of paclitaxel and other poorly soluble drugs.

KW - Aqueous stabilization

KW - Drug loading

KW - Hydrotropic agent

KW - Paclitaxel

KW - Polymer micelle

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VL - 342-343

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JO - Key Engineering Materials

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Aqueous solubilization of paclitaxel using hydrotropic polymer micelle

Abstract

Keywords

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