Association between a polymorphism (rs2071214) in baculoviral iap repeat containing 5 gene (BIRC5) and ischemic stroke in Korean population

Jinmann Chon, Hee Sang Kim, Dong Hwan Yun, Seung Don Yoo, Dong Hwan Kim, Seung Ah Lee, Su Kang Kim, Hae Jeong Park, Joo Ho Chung, Sungjoon Chung, Jinah Yeo

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6 Citations (Scopus)

Abstract

Objective To investigate whether baculoviral inhibitor of apoptosis (IAP) repeat containing 5 gene (BIRC5) polymorphisms are associated with the development and clinical phenotypes of ischemic stroke in Korea population. Methods We enrolled 121 ischemic stroke patients and 291 control subjects. Ischemic stroke patients were divided into subgroups according to the scores of National Institutes of Health Stroke Survey (<6 or =6) and Modified Barthel Index (<60 or =60). Single nucleotide polymorphisms (SNPs) of BIRC5 (rs3764383 and rs2071214) were selected and genotyped by direct sequencing for all subjects. Multiple logistic regression models (codominant 1 and 2, dominant, recessive, overdominant and log-additive) were used to estimate odds ratios (ORs), 95% confidence intervals (CIs), and p-values. Results In analysis of stroke susceptibility, the genotype and allele frequencies of rs3764383 exhibited no difference between the control group and the ischemic stroke group. SNP rs2071214 was associated with ischemic stroke in the codominant (p=0.003), dominant (p=0.002), overdominant (p=0.005), and log-additive (p=0.008) models, respectively. The G allele frequency of rs2071214 was significantly (p=0.009) associated with susceptibility for ischemic stroke (OR, 1.57; 95% CI, 1.12-2.21). However, in the analysis for clinical phenotype, no SNP of the BIRC5 gene was found to be associated with ischemic stroke. Conclusion These results suggest that a missense SNP (rs2071214) of BIRC5 may be associated with the development of ischemic stroke in the Korean population.

Original languageEnglish
Pages (from-to)392-400
Number of pages9
JournalAnnals of Rehabilitation Medicine
Volume40
Issue number3
DOIs
Publication statusPublished - 2016

Bibliographical note

Publisher Copyright:
© 2016 by Korean Academy of Rehabilitation Medicine.

Keywords

  • BIRC5 protein
  • Brain infarction
  • Single nucleotide polymorphism

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