Association between BH3 interacting domain death agonist (BID) gene polymorphism and ossification of the posterior longitudinal ligament in Korean population

Jinmann Chon, Jang Hyeok Hong, Jinsung Kim, Yoo Jin Han, Byoung Wook Lee, Soo Cheol Kim, Dong Hwan Kim, Seung Don Yoo, Hee Sang Kim, Dong Hwan Yun

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The purpose of this study was to investigate single nucleotide polymorphisms (SNPs) of the BH3 interacting domain death agonist (BID ) gene as a risk factor in Korean patients with ossification of the posterior longitudinal ligament (OPLL). To investigate the genetic association, two coding SNPs (rs8190315, Ser10Gly; rs2072392, Asp60Asp) of BID were genotyped in 157 OPLL patients and 209 control subjects. SNPStats, SNPAnalyzer Pro, Helixtree, and Haploview 4.2 programs were used for association analysis. Multiple logistic regression models (codominant, dominant, and recessive) were calculated for the odds ratios (ORs), 95% confidence intervals (CIs), and corresponding P values. For multiple testing, Bonferroni correction was performed. After Bonferroni correction, genotype analysis of both rs8190315 and rs2072392 showed association between the OPLL group and the control group in the codominant model ( P = 0.042, OR 1.86, 95% CI 1.10-3.15). A complete linkage disequilibrium block was estimated between the two SNPs. Both of the G allele of rs8190315 and C allele of rs2072392 were strongly associated with an increased risk in the development of OPLL (P = 0.0052, OR 2.66, 95% CI 1.51-4.68). These results suggest that BID is associated with OPLL, and both the G allele of a missense SNP (rs8190315, Ser10Gly) and C allele of a synonymous SNP (rs2072392, Asp60Asp) are risk factors for the development of OPLL in Korean population.

Original languageEnglish
Pages (from-to)895-899
Number of pages5
JournalMolecular Biology Reports
Volume41
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • BID
  • Disequilibrium
  • Haplotype
  • Linkage
  • Ossification of the posterior longitudinal ligament
  • Polymorphism

Fingerprint

Dive into the research topics of 'Association between BH3 interacting domain death agonist (BID) gene polymorphism and ossification of the posterior longitudinal ligament in Korean population'. Together they form a unique fingerprint.

Cite this