Association between interleukin-10 (IL-10) polymorphism (-1,082, A/G) and sjogren’s syndrome: An updated meta-analysis

To evaluate the association between the polymorphism (-1082, A/G) of the IL-10 gene and a susceptibility for Sjogren’s syndrome (SS). We searched electronic databases including PubMed, Scopus, and Embase databases, and a total of 5 studies including 903 healthy controls and 382 SS cases were analyzed. The meta-analysis of the -1082 polymorphism of the IL-10 gene was carried out with pooled ORs, 95% CI, and p value calculated using the allele, dominant and recessive model. Statistical significance was found in primary SS (pSS) cases in the allele model (G vs. A, OR=0.763, 95% CI=0.610-0.955, P=0.018) and the dominant model (G/G+G/A vs. A/A, OR=0.664, 95% CI=0.479-0.920, P=0.014). Our meta-analysis revealed that the polymorphism (-1,082, A/G) of the IL-10 gene might be related to a susceptibility for pSS.