TY - JOUR
T1 - Association between interleukin 15 receptor, alpha (IL15RA) polymorphism and Korean patients with ossification of the posterior longitudinal ligament
AU - Kim, Dong Hwan
AU - Jeong, Yong Seol
AU - Chon, Jinmann
AU - Yoo, Seung Don
AU - Kim, Hee Sang
AU - Kang, Sung Wook
AU - Chung, Joo Ho
AU - Kim, Ki Tack
AU - Yun, Dong Hwan
N1 - Funding Information:
This work was supported by a grant from the Kyung Hee University in 2007 ( KHU-20070706 ).
PY - 2011/9
Y1 - 2011/9
N2 - Objectives: Recently, a number of evidences have been reported concerning the genetic factor involved in the development of ossification of the posterior longitudinal ligament (OPLL). The purpose of this study was to investigate single nucleotide polymorphisms (SNPs) of the interleukin 15 receptor, alpha (IL15RA) gene as a risk factor in Korean patients with OPLL. Design: To investigate the genetic association, two coding SNPs (rs2296139, Thr73Thr; rs2228059, Asn182Thr) in IL15RA were genotyped in 166 OPLL patients and 230 control subjects. SNPStats, SNPAnalyzer, and Helixtree programs were used for association analysis. Results: In the present study, we found the association between a missense SNP (rs2228059) and the risk of OPLL in codominant (p = 0.0028, OR. = 1.58, 95% CI. = 1.17-2.14), dominant (p = 0.0071, OR. = 1.82, 95% CI. = 1.17-2.82), and recessive models (p = 0.036, OR. = 1.79, 95% CI. = 1.04-3.09). The frequency of rs2228059 allele was significantly associated with the susceptibility of OPLL (p = 0.0043, OR. = 1.52, 95% CI. = 1.14-2.02). After Bonferroni correction, the missense SNP (rs2228059, Asn182Thr) still had significant correlations (p = 0.0056 in codominant model; p = 0.0142 in dominant model; p = 0.0086 in allele analysis). Haplotype variation in IL15RA was associated with OPLL (global haplotype test, p = 0.025). Conclusions: These results suggest that IL15RA polymorphism may be associated with the susceptibility of OPLL in Korean population.
AB - Objectives: Recently, a number of evidences have been reported concerning the genetic factor involved in the development of ossification of the posterior longitudinal ligament (OPLL). The purpose of this study was to investigate single nucleotide polymorphisms (SNPs) of the interleukin 15 receptor, alpha (IL15RA) gene as a risk factor in Korean patients with OPLL. Design: To investigate the genetic association, two coding SNPs (rs2296139, Thr73Thr; rs2228059, Asn182Thr) in IL15RA were genotyped in 166 OPLL patients and 230 control subjects. SNPStats, SNPAnalyzer, and Helixtree programs were used for association analysis. Results: In the present study, we found the association between a missense SNP (rs2228059) and the risk of OPLL in codominant (p = 0.0028, OR. = 1.58, 95% CI. = 1.17-2.14), dominant (p = 0.0071, OR. = 1.82, 95% CI. = 1.17-2.82), and recessive models (p = 0.036, OR. = 1.79, 95% CI. = 1.04-3.09). The frequency of rs2228059 allele was significantly associated with the susceptibility of OPLL (p = 0.0043, OR. = 1.52, 95% CI. = 1.14-2.02). After Bonferroni correction, the missense SNP (rs2228059, Asn182Thr) still had significant correlations (p = 0.0056 in codominant model; p = 0.0142 in dominant model; p = 0.0086 in allele analysis). Haplotype variation in IL15RA was associated with OPLL (global haplotype test, p = 0.025). Conclusions: These results suggest that IL15RA polymorphism may be associated with the susceptibility of OPLL in Korean population.
KW - Alpha
KW - Association study
KW - Interleukin 15 receptor
KW - Ossification of the posterior longitudinal ligament
KW - Single nucleotide polymorphism
UR - http://www.scopus.com/inward/record.url?scp=79960893286&partnerID=8YFLogxK
U2 - 10.1016/j.cyto.2011.05.016
DO - 10.1016/j.cyto.2011.05.016
M3 - Article
C2 - 21689944
AN - SCOPUS:79960893286
SN - 1043-4666
VL - 55
SP - 343
EP - 346
JO - Cytokine
JF - Cytokine
IS - 3
ER -