Association between reninangiotensinaldosterone system-related genes and blood pressure in a Korean population

Se Bin Song; Hyun Seok Jin; Kyung Won Hong; Ji Eun Lim; Ju Young Moon; Kyung Hwan Jeong; Chun Gyoo Ihm; Tae Won Lee; Bermseok Oh; Sang Ho Lee

doi:10.3109/08037051.2011.555074

Association between reninangiotensinaldosterone system-related genes and blood pressure in a Korean population

Se Bin Song, Hyun Seok Jin, Kyung Won Hong, Ji Eun Lim, Ju Young Moon, Kyung Hwan Jeong, Chun Gyoo Ihm, Tae Won Lee, Bermseok Oh, Sang Ho Lee

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Aims. Blood pressure control is influenced by various genetic and environmental factors, and genetic susceptibility is important in the development of essential hypertension. Because the reninangiotensinaldosterone system (RAAS) has a key role in vasoconstriction, vasodilation, and sodium and electrolyte balance, it is central in blood pressure control and so is an appropriate target in hypertension treatments. The present study assessed the association of RAAS-related genes with blood pressure and hypertension in a Korean population. Single nucleotide polymorphisms (SNPs, n = 114) in nine RAAS-related genes (AGT, REN, ACE, ACE2, AGTR1, CYP11B2, NR3C2, MAS1, and CMA1) were assessed for their correlation with blood pressure and hypertension using genotype data of 8842 individuals from the Korea Association Resource subject pool. Major findings. Linear regression analysis revealed a statistically significant association with blood pressure of 10 SNPs in six genes (ACE, ACE2, CYP11B2, NR3C2, MAS1, and CMA1). An additional hypertension casecontrol study identified 10 SNPs in NR3C2 and ACE that were linked to hypertension. Principal conclusion. Three SNPs (rs11737660, rs6810951, and rs10519963) in NR3C2 correlate with both blood pressure and hypertension. Genetic polymorphisms in RAAS-related genes appear to be associated with hypertension in a Korean population.

Original language	English
Pages (from-to)	204-210
Number of pages	7
Journal	Blood Pressure
Volume	20
Issue number	4
DOIs	https://doi.org/10.3109/08037051.2011.555074
Publication status	Published - Aug 2011

Bibliographical note

Funding Information:
This study was supported by a grant from Kyung Hee University (KHU 20050455).

Keywords

Aldosterone
Blood pressure
Genes
Genetic
Hypertension
Polymorphism
Receptors
Reninangiotensin system

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10.3109/08037051.2011.555074

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title = "Association between reninangiotensinaldosterone system-related genes and blood pressure in a Korean population",

abstract = "Aims. Blood pressure control is influenced by various genetic and environmental factors, and genetic susceptibility is important in the development of essential hypertension. Because the reninangiotensinaldosterone system (RAAS) has a key role in vasoconstriction, vasodilation, and sodium and electrolyte balance, it is central in blood pressure control and so is an appropriate target in hypertension treatments. The present study assessed the association of RAAS-related genes with blood pressure and hypertension in a Korean population. Single nucleotide polymorphisms (SNPs, n = 114) in nine RAAS-related genes (AGT, REN, ACE, ACE2, AGTR1, CYP11B2, NR3C2, MAS1, and CMA1) were assessed for their correlation with blood pressure and hypertension using genotype data of 8842 individuals from the Korea Association Resource subject pool. Major findings. Linear regression analysis revealed a statistically significant association with blood pressure of 10 SNPs in six genes (ACE, ACE2, CYP11B2, NR3C2, MAS1, and CMA1). An additional hypertension casecontrol study identified 10 SNPs in NR3C2 and ACE that were linked to hypertension. Principal conclusion. Three SNPs (rs11737660, rs6810951, and rs10519963) in NR3C2 correlate with both blood pressure and hypertension. Genetic polymorphisms in RAAS-related genes appear to be associated with hypertension in a Korean population.",

keywords = "Aldosterone, Blood pressure, Genes, Genetic, Hypertension, Polymorphism, Receptors, Reninangiotensin system",

author = "Song, \{Se Bin\} and Jin, \{Hyun Seok\} and Hong, \{Kyung Won\} and Lim, \{Ji Eun\} and Moon, \{Ju Young\} and Jeong, \{Kyung Hwan\} and Ihm, \{Chun Gyoo\} and Lee, \{Tae Won\} and Bermseok Oh and Lee, \{Sang Ho\}",

note = "Funding Information: This study was supported by a grant from Kyung Hee University (KHU 20050455).",

year = "2011",

month = aug,

doi = "10.3109/08037051.2011.555074",

language = "English",

volume = "20",

pages = "204--210",

journal = "Blood Pressure",

issn = "0803-7051",

publisher = "Taylor and Francis Ltd.",

number = "4",

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T1 - Association between reninangiotensinaldosterone system-related genes and blood pressure in a Korean population

AU - Song, Se Bin

AU - Jin, Hyun Seok

AU - Hong, Kyung Won

AU - Lim, Ji Eun

AU - Moon, Ju Young

AU - Jeong, Kyung Hwan

AU - Ihm, Chun Gyoo

AU - Lee, Tae Won

AU - Oh, Bermseok

AU - Lee, Sang Ho

N1 - Funding Information: This study was supported by a grant from Kyung Hee University (KHU 20050455).

PY - 2011/8

Y1 - 2011/8

N2 - Aims. Blood pressure control is influenced by various genetic and environmental factors, and genetic susceptibility is important in the development of essential hypertension. Because the reninangiotensinaldosterone system (RAAS) has a key role in vasoconstriction, vasodilation, and sodium and electrolyte balance, it is central in blood pressure control and so is an appropriate target in hypertension treatments. The present study assessed the association of RAAS-related genes with blood pressure and hypertension in a Korean population. Single nucleotide polymorphisms (SNPs, n = 114) in nine RAAS-related genes (AGT, REN, ACE, ACE2, AGTR1, CYP11B2, NR3C2, MAS1, and CMA1) were assessed for their correlation with blood pressure and hypertension using genotype data of 8842 individuals from the Korea Association Resource subject pool. Major findings. Linear regression analysis revealed a statistically significant association with blood pressure of 10 SNPs in six genes (ACE, ACE2, CYP11B2, NR3C2, MAS1, and CMA1). An additional hypertension casecontrol study identified 10 SNPs in NR3C2 and ACE that were linked to hypertension. Principal conclusion. Three SNPs (rs11737660, rs6810951, and rs10519963) in NR3C2 correlate with both blood pressure and hypertension. Genetic polymorphisms in RAAS-related genes appear to be associated with hypertension in a Korean population.

AB - Aims. Blood pressure control is influenced by various genetic and environmental factors, and genetic susceptibility is important in the development of essential hypertension. Because the reninangiotensinaldosterone system (RAAS) has a key role in vasoconstriction, vasodilation, and sodium and electrolyte balance, it is central in blood pressure control and so is an appropriate target in hypertension treatments. The present study assessed the association of RAAS-related genes with blood pressure and hypertension in a Korean population. Single nucleotide polymorphisms (SNPs, n = 114) in nine RAAS-related genes (AGT, REN, ACE, ACE2, AGTR1, CYP11B2, NR3C2, MAS1, and CMA1) were assessed for their correlation with blood pressure and hypertension using genotype data of 8842 individuals from the Korea Association Resource subject pool. Major findings. Linear regression analysis revealed a statistically significant association with blood pressure of 10 SNPs in six genes (ACE, ACE2, CYP11B2, NR3C2, MAS1, and CMA1). An additional hypertension casecontrol study identified 10 SNPs in NR3C2 and ACE that were linked to hypertension. Principal conclusion. Three SNPs (rs11737660, rs6810951, and rs10519963) in NR3C2 correlate with both blood pressure and hypertension. Genetic polymorphisms in RAAS-related genes appear to be associated with hypertension in a Korean population.

KW - Aldosterone

KW - Blood pressure

KW - Genes

KW - Genetic

KW - Hypertension

KW - Polymorphism

KW - Receptors

KW - Reninangiotensin system

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IS - 4

ER -

Association between reninangiotensinaldosterone system-related genes and blood pressure in a Korean population

Abstract

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Keywords

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