Association between the SPRY1 gene polymorphism and obesity-related traits and osteoporosis in Korean women

Hyun Seok Jin; Bo Young Kim; Jeonghyun Kim; Kyung Won Hong; Suk Yul Jung; Yun Seok Lee; Dam Huh; Bermseok Oh; Yoon Sok Chung; Seon Yong Jeong

doi:10.1016/j.ymgme.2012.10.017

Association between the SPRY1 gene polymorphism and obesity-related traits and osteoporosis in Korean women

Hyun Seok Jin, Bo Young Kim, Jeonghyun Kim, Kyung Won Hong, Suk Yul Jung, Yun Seok Lee, Dam Huh, Bermseok Oh, Yoon Sok Chung, Seon Yong Jeong

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Background: Emerging evidence has revealed a close relationship between obesity and osteoporosis. It was reported recently that conditional knockout of the Spry1 gene in mice adipocytes causes an increase in body fat and a decrease in bone mass, and that these phenotypes are rescued by Spry1 overexpression in adipose tissue. In this study, we investigated whether genetic variation in the human SPRY1 gene is associated with obesity-related phenotypes and/or osteoporosis in humans. Methods: We performed a candidate gene association analysis between the four single nucleotide polymorphisms (SNPs) and 14 imputed SNPs in the SPRY1 gene and obesity-related traits and osteoporosis in a Korean women cohort (3013 subjects). Results: All four SPRY1 gene SNPs were significantly associated with either obesity-related traits or osteoporosis. The TGCC haplotype in the SRPY1 gene showed simultaneous association with an increased risk for obesity-related traits, percentage body fat (p=0.0087) and percentage abdominal fat (p=0.047), and osteoporosis (odds ratio=1.50; p=. 0.025) in the recessive genetic model. Conclusions: Our results support a previous finding in conditional Spry1 gene knockout mice and suggest that the SPRY1 gene is an important genetic factor for determining the risk of both obesity and osteoporosis in humans.

Original language	English
Pages (from-to)	95-101
Number of pages	7
Journal	Molecular Genetics and Metabolism
Volume	108
Issue number	1
DOIs	https://doi.org/10.1016/j.ymgme.2012.10.017
Publication status	Published - Jan 2013

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (MEST) ( KRF-2009-0093189 ) and the High Value-added Food Technology Development Program, Ministry for Food, Agriculture, Forestry, and Fisheries, Republic of Korea ( 111133-03-1-SB020 ). We thank the Korea Center for Disease Control, of the Korea National Institute of Health for providing clinical information and genotype data. This study was performed within the Consortium for Large Scale Genome Wide Association Study III (2011E7300400), which was supported by genotypic (the Korean Genome Analysis Project, 4845-301) and phenotypic data (the Korean Genome Epidemiology Study, 4851-302) from the Korean Center for Disease Control.

Keywords

Association
Haplotype
Obesity
Osteoporosis
SPRY1
Single nucleotide polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ymgme.2012.10.017

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title = "Association between the SPRY1 gene polymorphism and obesity-related traits and osteoporosis in Korean women",

abstract = "Background: Emerging evidence has revealed a close relationship between obesity and osteoporosis. It was reported recently that conditional knockout of the Spry1 gene in mice adipocytes causes an increase in body fat and a decrease in bone mass, and that these phenotypes are rescued by Spry1 overexpression in adipose tissue. In this study, we investigated whether genetic variation in the human SPRY1 gene is associated with obesity-related phenotypes and/or osteoporosis in humans. Methods: We performed a candidate gene association analysis between the four single nucleotide polymorphisms (SNPs) and 14 imputed SNPs in the SPRY1 gene and obesity-related traits and osteoporosis in a Korean women cohort (3013 subjects). Results: All four SPRY1 gene SNPs were significantly associated with either obesity-related traits or osteoporosis. The TGCC haplotype in the SRPY1 gene showed simultaneous association with an increased risk for obesity-related traits, percentage body fat (p=0.0087) and percentage abdominal fat (p=0.047), and osteoporosis (odds ratio=1.50; p=. 0.025) in the recessive genetic model. Conclusions: Our results support a previous finding in conditional Spry1 gene knockout mice and suggest that the SPRY1 gene is an important genetic factor for determining the risk of both obesity and osteoporosis in humans.",

keywords = "Association, Haplotype, Obesity, Osteoporosis, SPRY1, Single nucleotide polymorphism",

author = "Jin, {Hyun Seok} and Kim, {Bo Young} and Jeonghyun Kim and Hong, {Kyung Won} and Jung, {Suk Yul} and Lee, {Yun Seok} and Dam Huh and Bermseok Oh and Chung, {Yoon Sok} and Jeong, {Seon Yong}",

note = "Funding Information: This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (MEST) ( KRF-2009-0093189 ) and the High Value-added Food Technology Development Program, Ministry for Food, Agriculture, Forestry, and Fisheries, Republic of Korea ( 111133-03-1-SB020 ). We thank the Korea Center for Disease Control, of the Korea National Institute of Health for providing clinical information and genotype data. This study was performed within the Consortium for Large Scale Genome Wide Association Study III (2011E7300400), which was supported by genotypic (the Korean Genome Analysis Project, 4845-301) and phenotypic data (the Korean Genome Epidemiology Study, 4851-302) from the Korean Center for Disease Control.",

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doi = "10.1016/j.ymgme.2012.10.017",

language = "English",

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AU - Kim, Bo Young

AU - Kim, Jeonghyun

AU - Hong, Kyung Won

AU - Jung, Suk Yul

AU - Lee, Yun Seok

AU - Huh, Dam

AU - Oh, Bermseok

AU - Chung, Yoon Sok

AU - Jeong, Seon Yong

N1 - Funding Information: This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (MEST) ( KRF-2009-0093189 ) and the High Value-added Food Technology Development Program, Ministry for Food, Agriculture, Forestry, and Fisheries, Republic of Korea ( 111133-03-1-SB020 ). We thank the Korea Center for Disease Control, of the Korea National Institute of Health for providing clinical information and genotype data. This study was performed within the Consortium for Large Scale Genome Wide Association Study III (2011E7300400), which was supported by genotypic (the Korean Genome Analysis Project, 4845-301) and phenotypic data (the Korean Genome Epidemiology Study, 4851-302) from the Korean Center for Disease Control.

PY - 2013/1

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N2 - Background: Emerging evidence has revealed a close relationship between obesity and osteoporosis. It was reported recently that conditional knockout of the Spry1 gene in mice adipocytes causes an increase in body fat and a decrease in bone mass, and that these phenotypes are rescued by Spry1 overexpression in adipose tissue. In this study, we investigated whether genetic variation in the human SPRY1 gene is associated with obesity-related phenotypes and/or osteoporosis in humans. Methods: We performed a candidate gene association analysis between the four single nucleotide polymorphisms (SNPs) and 14 imputed SNPs in the SPRY1 gene and obesity-related traits and osteoporosis in a Korean women cohort (3013 subjects). Results: All four SPRY1 gene SNPs were significantly associated with either obesity-related traits or osteoporosis. The TGCC haplotype in the SRPY1 gene showed simultaneous association with an increased risk for obesity-related traits, percentage body fat (p=0.0087) and percentage abdominal fat (p=0.047), and osteoporosis (odds ratio=1.50; p=. 0.025) in the recessive genetic model. Conclusions: Our results support a previous finding in conditional Spry1 gene knockout mice and suggest that the SPRY1 gene is an important genetic factor for determining the risk of both obesity and osteoporosis in humans.

AB - Background: Emerging evidence has revealed a close relationship between obesity and osteoporosis. It was reported recently that conditional knockout of the Spry1 gene in mice adipocytes causes an increase in body fat and a decrease in bone mass, and that these phenotypes are rescued by Spry1 overexpression in adipose tissue. In this study, we investigated whether genetic variation in the human SPRY1 gene is associated with obesity-related phenotypes and/or osteoporosis in humans. Methods: We performed a candidate gene association analysis between the four single nucleotide polymorphisms (SNPs) and 14 imputed SNPs in the SPRY1 gene and obesity-related traits and osteoporosis in a Korean women cohort (3013 subjects). Results: All four SPRY1 gene SNPs were significantly associated with either obesity-related traits or osteoporosis. The TGCC haplotype in the SRPY1 gene showed simultaneous association with an increased risk for obesity-related traits, percentage body fat (p=0.0087) and percentage abdominal fat (p=0.047), and osteoporosis (odds ratio=1.50; p=. 0.025) in the recessive genetic model. Conclusions: Our results support a previous finding in conditional Spry1 gene knockout mice and suggest that the SPRY1 gene is an important genetic factor for determining the risk of both obesity and osteoporosis in humans.

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KW - Haplotype

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Association between the SPRY1 gene polymorphism and obesity-related traits and osteoporosis in Korean women

Abstract

Bibliographical note

Keywords

UN SDGs

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