Association of interleukin-18 gene polymorphisms with hepatitis b virus clearance

Jae Youn Cheong; Sung Won Cho; Bermseok Oh; Kuchan Kimm; Kee Myung Lee; Sung Jae Shin; Jung A. Lee; Byung Lae Park; Hyun Sub Cheong; Hyoung Doo Shin; Bo Young Cho; Jin Hong Kim

doi:10.1007/s10620-009-0819-z

Association of interleukin-18 gene polymorphisms with hepatitis b virus clearance

Jae Youn Cheong, Sung Won Cho, Bermseok Oh, Kuchan Kimm, Kee Myung Lee, Sung Jae Shin, Jung A. Lee, Byung Lae Park, Hyun Sub Cheong, Hyoung Doo Shin, Bo Young Cho, Jin Hong Kim

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-γ-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean subjects were enrolled in the study and divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions -667G>T, -148G>C, +8925C>G, and +13925A>C. We observed that the subjects bearing the IL-18 -148C allele [odds ratio (OR), 0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; P = 0.01) were significantly associated with HBV clearance in a recessive model. This study indicates that the -148C, +8925G, and +13925C alleles of the IL-18 gene are likely associated with HBV clearance in a Korean population.

Original language	English
Pages (from-to)	1113-1119
Number of pages	7
Journal	Digestive Diseases and Sciences
Volume	55
Issue number	4
DOIs	https://doi.org/10.1007/s10620-009-0819-z
Publication status	Published - Apr 2010

Bibliographical note

Funding Information:
Acknowledgments This study was supported by a grant from the Korean Health R&D project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A010383).

Keywords

Hepatitis B
Interleukin-18 (IL-18)
Single-nucleotide polymorphism (SNP)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10620-009-0819-z

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@article{f2ad21fcac534c76acb77660be56725c,

title = "Association of interleukin-18 gene polymorphisms with hepatitis b virus clearance",

abstract = "The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-γ-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean subjects were enrolled in the study and divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions -667G>T, -148G>C, +8925C>G, and +13925A>C. We observed that the subjects bearing the IL-18 -148C allele [odds ratio (OR), 0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; P = 0.01) were significantly associated with HBV clearance in a recessive model. This study indicates that the -148C, +8925G, and +13925C alleles of the IL-18 gene are likely associated with HBV clearance in a Korean population.",

keywords = "Hepatitis B, Interleukin-18 (IL-18), Single-nucleotide polymorphism (SNP)",

author = "Cheong, {Jae Youn} and Cho, {Sung Won} and Bermseok Oh and Kuchan Kimm and Lee, {Kee Myung} and Shin, {Sung Jae} and Lee, {Jung A.} and Park, {Byung Lae} and Cheong, {Hyun Sub} and Shin, {Hyoung Doo} and Cho, {Bo Young} and Kim, {Jin Hong}",

note = "Funding Information: Acknowledgments This study was supported by a grant from the Korean Health R&D project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A010383).",

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doi = "10.1007/s10620-009-0819-z",

language = "English",

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T1 - Association of interleukin-18 gene polymorphisms with hepatitis b virus clearance

AU - Cheong, Jae Youn

AU - Cho, Sung Won

AU - Oh, Bermseok

AU - Kimm, Kuchan

AU - Lee, Kee Myung

AU - Shin, Sung Jae

AU - Lee, Jung A.

AU - Park, Byung Lae

AU - Cheong, Hyun Sub

AU - Shin, Hyoung Doo

AU - Cho, Bo Young

AU - Kim, Jin Hong

N1 - Funding Information: Acknowledgments This study was supported by a grant from the Korean Health R&D project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A010383).

PY - 2010/4

Y1 - 2010/4

N2 - The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-γ-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean subjects were enrolled in the study and divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions -667G>T, -148G>C, +8925C>G, and +13925A>C. We observed that the subjects bearing the IL-18 -148C allele [odds ratio (OR), 0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; P = 0.01) were significantly associated with HBV clearance in a recessive model. This study indicates that the -148C, +8925G, and +13925C alleles of the IL-18 gene are likely associated with HBV clearance in a Korean population.

AB - The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-γ-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean subjects were enrolled in the study and divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions -667G>T, -148G>C, +8925C>G, and +13925A>C. We observed that the subjects bearing the IL-18 -148C allele [odds ratio (OR), 0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; P = 0.01) were significantly associated with HBV clearance in a recessive model. This study indicates that the -148C, +8925G, and +13925C alleles of the IL-18 gene are likely associated with HBV clearance in a Korean population.

KW - Hepatitis B

KW - Interleukin-18 (IL-18)

KW - Single-nucleotide polymorphism (SNP)

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SN - 0163-2116

VL - 55

SP - 1113

EP - 1119

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

IS - 4

ER -

Association of interleukin-18 gene polymorphisms with hepatitis b virus clearance

Abstract

Bibliographical note

Keywords

UN SDGs

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