Association of UVRAG polymorphisms with susceptibility to non-segmental vitiligo in a Korean sample

Taek Jo Jeong; Min Kyung Shin; Yoon Kyung Uhm; Hak Jae Kim; Joo Ho Chung; Mu Hyoung Lee

doi:10.1111/j.1600-0625.2009.01039.x

Association of UVRAG polymorphisms with susceptibility to non-segmental vitiligo in a Korean sample

Taek Jo Jeong, Min Kyung Shin, Yoon Kyung Uhm, Hak Jae Kim, Joo Ho Chung, Mu Hyoung Lee

Research output: Contribution to journal › Letter › peer-review

30 Citations (Scopus)

Abstract

Autoimmune, self-destructive, oxidative stress and genetic theories have been proposed for the pathogenesis of vitiligo. Autophagy is essential for cellular homeostasis and is implicated in many pathophysiological conditions such as cancer, response to oxidative stress and autoimmunity. The ultraviolet (UV) radiation resistance-associated gene (UVRAG) activates the Beclin1-PI(3)KC3 complex, promoting autophagy. To evaluate whether UVRAG polymorphisms are associated with non-segmental vitiligo (NSV) patients in a Korean sample, we conducted a case-control association study of 225 NSV patients and 439 matched healthy controls. A total of five single nucleotide polymorphisms (SNPs) of UVRAG were selected for analysis. Among these, two SNPs (rs1458836, rs7933235) showed significant genotypic differences between the NSV patient group and the control group. These two SNPs were located within a strong linkage disequilibrium (LD) block. In addition, the haplotype of the UVRAG polymorphism was associated with NSV. This study suggests a possible association between UVRAG and NSV susceptibility.

Original language	English
Pages (from-to)	e323-e325
Journal	Experimental Dermatology
Volume	19
Issue number	8
DOIs	https://doi.org/10.1111/j.1600-0625.2009.01039.x
Publication status	Published - Aug 2010

Keywords

Non-segmental vitiligo
Single nucleotide polymorphisms
UVRAG

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0625.2009.01039.x

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title = "Association of UVRAG polymorphisms with susceptibility to non-segmental vitiligo in a Korean sample",

abstract = "Autoimmune, self-destructive, oxidative stress and genetic theories have been proposed for the pathogenesis of vitiligo. Autophagy is essential for cellular homeostasis and is implicated in many pathophysiological conditions such as cancer, response to oxidative stress and autoimmunity. The ultraviolet (UV) radiation resistance-associated gene (UVRAG) activates the Beclin1-PI(3)KC3 complex, promoting autophagy. To evaluate whether UVRAG polymorphisms are associated with non-segmental vitiligo (NSV) patients in a Korean sample, we conducted a case-control association study of 225 NSV patients and 439 matched healthy controls. A total of five single nucleotide polymorphisms (SNPs) of UVRAG were selected for analysis. Among these, two SNPs (rs1458836, rs7933235) showed significant genotypic differences between the NSV patient group and the control group. These two SNPs were located within a strong linkage disequilibrium (LD) block. In addition, the haplotype of the UVRAG polymorphism was associated with NSV. This study suggests a possible association between UVRAG and NSV susceptibility.",

keywords = "Non-segmental vitiligo, Single nucleotide polymorphisms, UVRAG",

author = "Jeong, {Taek Jo} and Shin, {Min Kyung} and Uhm, {Yoon Kyung} and Kim, {Hak Jae} and Chung, {Joo Ho} and Lee, {Mu Hyoung}",

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doi = "10.1111/j.1600-0625.2009.01039.x",

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AU - Jeong, Taek Jo

AU - Shin, Min Kyung

AU - Uhm, Yoon Kyung

AU - Kim, Hak Jae

AU - Chung, Joo Ho

AU - Lee, Mu Hyoung

PY - 2010/8

Y1 - 2010/8

N2 - Autoimmune, self-destructive, oxidative stress and genetic theories have been proposed for the pathogenesis of vitiligo. Autophagy is essential for cellular homeostasis and is implicated in many pathophysiological conditions such as cancer, response to oxidative stress and autoimmunity. The ultraviolet (UV) radiation resistance-associated gene (UVRAG) activates the Beclin1-PI(3)KC3 complex, promoting autophagy. To evaluate whether UVRAG polymorphisms are associated with non-segmental vitiligo (NSV) patients in a Korean sample, we conducted a case-control association study of 225 NSV patients and 439 matched healthy controls. A total of five single nucleotide polymorphisms (SNPs) of UVRAG were selected for analysis. Among these, two SNPs (rs1458836, rs7933235) showed significant genotypic differences between the NSV patient group and the control group. These two SNPs were located within a strong linkage disequilibrium (LD) block. In addition, the haplotype of the UVRAG polymorphism was associated with NSV. This study suggests a possible association between UVRAG and NSV susceptibility.

AB - Autoimmune, self-destructive, oxidative stress and genetic theories have been proposed for the pathogenesis of vitiligo. Autophagy is essential for cellular homeostasis and is implicated in many pathophysiological conditions such as cancer, response to oxidative stress and autoimmunity. The ultraviolet (UV) radiation resistance-associated gene (UVRAG) activates the Beclin1-PI(3)KC3 complex, promoting autophagy. To evaluate whether UVRAG polymorphisms are associated with non-segmental vitiligo (NSV) patients in a Korean sample, we conducted a case-control association study of 225 NSV patients and 439 matched healthy controls. A total of five single nucleotide polymorphisms (SNPs) of UVRAG were selected for analysis. Among these, two SNPs (rs1458836, rs7933235) showed significant genotypic differences between the NSV patient group and the control group. These two SNPs were located within a strong linkage disequilibrium (LD) block. In addition, the haplotype of the UVRAG polymorphism was associated with NSV. This study suggests a possible association between UVRAG and NSV susceptibility.

KW - Non-segmental vitiligo

KW - Single nucleotide polymorphisms

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JO - Experimental Dermatology

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ER -

Association of UVRAG polymorphisms with susceptibility to non-segmental vitiligo in a Korean sample

Abstract

Keywords

UN SDGs

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