Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology

Byoung Kwon Yoo; Luni Emdad; Seok Geun Lee; Zao Zhong Su; Prasanna Santhekadur; Dong Chen; Rachel Gredler; Paul B. Fisher; Devanand Sarkar

doi:10.1016/j.pharmthera.2011.01.008

Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology

Byoung Kwon Yoo, Luni Emdad, Seok Geun Lee, Zao Zhong Su, Prasanna Santhekadur, Dong Chen, Rachel Gredler, Paul B. Fisher, Devanand Sarkar

Research output: Contribution to journal › Review article › peer-review

121 Citations (Scopus)

Abstract

Since its initial identification and cloning in 2002, Astrocyte Elevated Gene-1 (AEG-1), also known as metadherin (MTDH), 3D3 and LYsine-RIch CEACAM1 co-isolated (LYRIC), has emerged as an important oncogene that is overexpressed in all cancers analyzed so far. Examination of a large cohort of patient samples representing diverse cancer indications has revealed progressive increase in AEG-1 expression with stages and grades of the disease and an inverse relationship between AEG-1 expression level and patient prognosis. AEG-1 functions as a bona fide oncogene by promoting transformation. In addition, it plays a significant role in invasion, metastasis, angiogenesis and chemoresistance, all important hallmarks of an aggressive cancer. AEG-1 is also implicated in diverse physiological and pathological processes, such as development, inflammation, neurodegeneration, migraine and Huntington's disease. AEG-1 is a highly basic protein with a transmembrane domain and multiple nuclear localization signals and it is present in the cell membrane, cytoplasm, nucleus, nucleolus and endoplasmic reticulum. In each location, AEG-1 interacts with specific proteins thereby modulating diverse intracellular processes the combination of which contributes to its pleiotrophic properties. The present review provides a snapshot of the current literature along with future perspectives on this unique molecule.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Pharmacology and Therapeutics
Volume	130
Issue number	1
DOIs	https://doi.org/10.1016/j.pharmthera.2011.01.008
Publication status	Published - Apr 2011

Bibliographical note

Funding Information:
The present study was supported in part by grants from The Goldhirsh Foundation and The Dana Foundation and National Cancer Institute Grant R01 CA138540-01A1 (DS); National Institutes of Health Grants R01 CA134721 and P01 CA104177 and the National Foundation for Cancer Research (PBF); and NRF Basic Science Research Program of the Korean Ministry of Education, Science and Technology (No. 2010-0008219 ) (SGL). DS is the Harrison Endowed Scholar in Cancer Research and a Blick Scholar. PBF holds the Thelma Newmeyer Corman Chair in Cancer Research and is a Samuel Waxman Cancer Research Foundation (SWCRF) investigator.

Keywords

Angiogenesis
Astrocyte elevated gene-1 (AEG-1)
Chemoresistance
Metastasis
Neurodegeneration
Oncogene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pharmthera.2011.01.008

Cite this

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title = "Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology",

abstract = "Since its initial identification and cloning in 2002, Astrocyte Elevated Gene-1 (AEG-1), also known as metadherin (MTDH), 3D3 and LYsine-RIch CEACAM1 co-isolated (LYRIC), has emerged as an important oncogene that is overexpressed in all cancers analyzed so far. Examination of a large cohort of patient samples representing diverse cancer indications has revealed progressive increase in AEG-1 expression with stages and grades of the disease and an inverse relationship between AEG-1 expression level and patient prognosis. AEG-1 functions as a bona fide oncogene by promoting transformation. In addition, it plays a significant role in invasion, metastasis, angiogenesis and chemoresistance, all important hallmarks of an aggressive cancer. AEG-1 is also implicated in diverse physiological and pathological processes, such as development, inflammation, neurodegeneration, migraine and Huntington's disease. AEG-1 is a highly basic protein with a transmembrane domain and multiple nuclear localization signals and it is present in the cell membrane, cytoplasm, nucleus, nucleolus and endoplasmic reticulum. In each location, AEG-1 interacts with specific proteins thereby modulating diverse intracellular processes the combination of which contributes to its pleiotrophic properties. The present review provides a snapshot of the current literature along with future perspectives on this unique molecule.",

keywords = "Angiogenesis, Astrocyte elevated gene-1 (AEG-1), Chemoresistance, Metastasis, Neurodegeneration, Oncogene",

author = "Yoo, {Byoung Kwon} and Luni Emdad and Lee, {Seok Geun} and Su, {Zao Zhong} and Prasanna Santhekadur and Dong Chen and Rachel Gredler and Fisher, {Paul B.} and Devanand Sarkar",

note = "Funding Information: The present study was supported in part by grants from The Goldhirsh Foundation and The Dana Foundation and National Cancer Institute Grant R01 CA138540-01A1 (DS); National Institutes of Health Grants R01 CA134721 and P01 CA104177 and the National Foundation for Cancer Research (PBF); and NRF Basic Science Research Program of the Korean Ministry of Education, Science and Technology (No. 2010-0008219 ) (SGL). DS is the Harrison Endowed Scholar in Cancer Research and a Blick Scholar. PBF holds the Thelma Newmeyer Corman Chair in Cancer Research and is a Samuel Waxman Cancer Research Foundation (SWCRF) investigator.",

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AU - Yoo, Byoung Kwon

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AU - Lee, Seok Geun

AU - Su, Zao Zhong

AU - Santhekadur, Prasanna

AU - Chen, Dong

AU - Gredler, Rachel

AU - Fisher, Paul B.

AU - Sarkar, Devanand

N1 - Funding Information: The present study was supported in part by grants from The Goldhirsh Foundation and The Dana Foundation and National Cancer Institute Grant R01 CA138540-01A1 (DS); National Institutes of Health Grants R01 CA134721 and P01 CA104177 and the National Foundation for Cancer Research (PBF); and NRF Basic Science Research Program of the Korean Ministry of Education, Science and Technology (No. 2010-0008219 ) (SGL). DS is the Harrison Endowed Scholar in Cancer Research and a Blick Scholar. PBF holds the Thelma Newmeyer Corman Chair in Cancer Research and is a Samuel Waxman Cancer Research Foundation (SWCRF) investigator.

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N2 - Since its initial identification and cloning in 2002, Astrocyte Elevated Gene-1 (AEG-1), also known as metadherin (MTDH), 3D3 and LYsine-RIch CEACAM1 co-isolated (LYRIC), has emerged as an important oncogene that is overexpressed in all cancers analyzed so far. Examination of a large cohort of patient samples representing diverse cancer indications has revealed progressive increase in AEG-1 expression with stages and grades of the disease and an inverse relationship between AEG-1 expression level and patient prognosis. AEG-1 functions as a bona fide oncogene by promoting transformation. In addition, it plays a significant role in invasion, metastasis, angiogenesis and chemoresistance, all important hallmarks of an aggressive cancer. AEG-1 is also implicated in diverse physiological and pathological processes, such as development, inflammation, neurodegeneration, migraine and Huntington's disease. AEG-1 is a highly basic protein with a transmembrane domain and multiple nuclear localization signals and it is present in the cell membrane, cytoplasm, nucleus, nucleolus and endoplasmic reticulum. In each location, AEG-1 interacts with specific proteins thereby modulating diverse intracellular processes the combination of which contributes to its pleiotrophic properties. The present review provides a snapshot of the current literature along with future perspectives on this unique molecule.

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KW - Metastasis

KW - Neurodegeneration

KW - Oncogene

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ER -

Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology

Abstract

Bibliographical note

Keywords

UN SDGs

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