Autoantibodies against aminoacyl-tRNA synthetase: Novel diagnostic marker for type 1 diabetes mellitus

Sang Gyu Park; Ho Seon Park; In Kyong Jeong; Young Min Cho; Hong Kyu Lee; Young Sun Kang; Sunghoon Kim; Kyong Soo Park

doi:10.3109/13547501003777823

Autoantibodies against aminoacyl-tRNA synthetase: Novel diagnostic marker for type 1 diabetes mellitus

Sang Gyu Park
, Ho Seon Park
, In Kyong Jeong
, Young Min Cho
, Hong Kyu Lee
, Young Sun Kang
, Sunghoon Kim
, Kyong Soo Park

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Objectives: To investigate whether or not antiaminoacyl-tRNA synthetase (aaRS) autoantibodies could be detected in patients with type 1 diabetes mellitus (DM) and be used as a diagnostic marker for type 1 DM, autoantibodies against aaRSs were measured in the plasma of normal subjects, patients with type 1 DM and patients with type 2 DM. Methods: An enzyme-linked immunosorbent assay was performed to detect anti-aaRS autoantibodies in the plasma of normal subjects, and patients with type 1 DM, and patients with type 2 DM. Results: From the 65 (normal), 58 (type 1 DM) and 57 (type 2 DM) subjects, anti-aaRS autoantibodies were found in 37.9% of patients with type 1 DM compared with 1.54% of the non-diabetic controls, and 5.26% of the patients with type 2 DM (p <0.0001). In addition, anti-aaRS autoantibodies were identified in 30% of patients with type 1 DM without classical type 1 DM autoantibodies. Conclusion: Anti-aaRS autoantibodies were identified in 37.9% of patients with type 1 DM. The results of this study demonstrate for the first time that autoantibodies against aaRSs are specifically associated with type 1 DM.

Original language	English
Pages (from-to)	358-366
Number of pages	9
Journal	Biomarkers
Volume	15
Issue number	4
DOIs	https://doi.org/10.3109/13547501003777823
Publication status	Published - Jun 2010

Bibliographical note

Funding Information:
This work was supported by a grant No 04-2008-053 from the SNUH research fund, and a grant (CHAIACF-2009-NS13) from the CHA University, and a grant from the Korea Health 21 R & D Project, Ministry of Health, Welfare and Family Affair, Republic of Korea (00-PJ3-PG6-GN07-001), and the grants of National Research Foundation (NRF-2008-359-C00024), 21C Frontier Functional Proteomics Project from Korean Ministry of Science and Technology (FPR08-B1-250), the WCU Project of the Ministry of Education, Science, and Technology (R31-2008-000-10103-0) and Gyonggi-do.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antisynthetase syndrome
Autoantibody
Autoimmune disease
ELISA
Pancreas

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10.3109/13547501003777823

Cite this

@article{1e56f084200442178ca10abfd8c4aef3,

title = "Autoantibodies against aminoacyl-tRNA synthetase: Novel diagnostic marker for type 1 diabetes mellitus",

abstract = "Objectives: To investigate whether or not antiaminoacyl-tRNA synthetase (aaRS) autoantibodies could be detected in patients with type 1 diabetes mellitus (DM) and be used as a diagnostic marker for type 1 DM, autoantibodies against aaRSs were measured in the plasma of normal subjects, patients with type 1 DM and patients with type 2 DM. Methods: An enzyme-linked immunosorbent assay was performed to detect anti-aaRS autoantibodies in the plasma of normal subjects, and patients with type 1 DM, and patients with type 2 DM. Results: From the 65 (normal), 58 (type 1 DM) and 57 (type 2 DM) subjects, anti-aaRS autoantibodies were found in 37.9\% of patients with type 1 DM compared with 1.54\% of the non-diabetic controls, and 5.26\% of the patients with type 2 DM (p <0.0001). In addition, anti-aaRS autoantibodies were identified in 30\% of patients with type 1 DM without classical type 1 DM autoantibodies. Conclusion: Anti-aaRS autoantibodies were identified in 37.9\% of patients with type 1 DM. The results of this study demonstrate for the first time that autoantibodies against aaRSs are specifically associated with type 1 DM.",

keywords = "Antisynthetase syndrome, Autoantibody, Autoimmune disease, ELISA, Pancreas",

author = "Park, \{Sang Gyu\} and Park, \{Ho Seon\} and Jeong, \{In Kyong\} and Cho, \{Young Min\} and Lee, \{Hong Kyu\} and Kang, \{Young Sun\} and Sunghoon Kim and Park, \{Kyong Soo\}",

note = "Funding Information: This work was supported by a grant No 04-2008-053 from the SNUH research fund, and a grant (CHAIACF-2009-NS13) from the CHA University, and a grant from the Korea Health 21 R \& D Project, Ministry of Health, Welfare and Family Affair, Republic of Korea (00-PJ3-PG6-GN07-001), and the grants of National Research Foundation (NRF-2008-359-C00024), 21C Frontier Functional Proteomics Project from Korean Ministry of Science and Technology (FPR08-B1-250), the WCU Project of the Ministry of Education, Science, and Technology (R31-2008-000-10103-0) and Gyonggi-do.",

year = "2010",

month = jun,

doi = "10.3109/13547501003777823",

language = "English",

volume = "15",

pages = "358--366",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Taylor and Francis Ltd.",

number = "4",

}

TY - JOUR

T1 - Autoantibodies against aminoacyl-tRNA synthetase

T2 - Novel diagnostic marker for type 1 diabetes mellitus

AU - Park, Sang Gyu

AU - Park, Ho Seon

AU - Jeong, In Kyong

AU - Cho, Young Min

AU - Lee, Hong Kyu

AU - Kang, Young Sun

AU - Kim, Sunghoon

AU - Park, Kyong Soo

N1 - Funding Information: This work was supported by a grant No 04-2008-053 from the SNUH research fund, and a grant (CHAIACF-2009-NS13) from the CHA University, and a grant from the Korea Health 21 R & D Project, Ministry of Health, Welfare and Family Affair, Republic of Korea (00-PJ3-PG6-GN07-001), and the grants of National Research Foundation (NRF-2008-359-C00024), 21C Frontier Functional Proteomics Project from Korean Ministry of Science and Technology (FPR08-B1-250), the WCU Project of the Ministry of Education, Science, and Technology (R31-2008-000-10103-0) and Gyonggi-do.

PY - 2010/6

Y1 - 2010/6

N2 - Objectives: To investigate whether or not antiaminoacyl-tRNA synthetase (aaRS) autoantibodies could be detected in patients with type 1 diabetes mellitus (DM) and be used as a diagnostic marker for type 1 DM, autoantibodies against aaRSs were measured in the plasma of normal subjects, patients with type 1 DM and patients with type 2 DM. Methods: An enzyme-linked immunosorbent assay was performed to detect anti-aaRS autoantibodies in the plasma of normal subjects, and patients with type 1 DM, and patients with type 2 DM. Results: From the 65 (normal), 58 (type 1 DM) and 57 (type 2 DM) subjects, anti-aaRS autoantibodies were found in 37.9% of patients with type 1 DM compared with 1.54% of the non-diabetic controls, and 5.26% of the patients with type 2 DM (p <0.0001). In addition, anti-aaRS autoantibodies were identified in 30% of patients with type 1 DM without classical type 1 DM autoantibodies. Conclusion: Anti-aaRS autoantibodies were identified in 37.9% of patients with type 1 DM. The results of this study demonstrate for the first time that autoantibodies against aaRSs are specifically associated with type 1 DM.

AB - Objectives: To investigate whether or not antiaminoacyl-tRNA synthetase (aaRS) autoantibodies could be detected in patients with type 1 diabetes mellitus (DM) and be used as a diagnostic marker for type 1 DM, autoantibodies against aaRSs were measured in the plasma of normal subjects, patients with type 1 DM and patients with type 2 DM. Methods: An enzyme-linked immunosorbent assay was performed to detect anti-aaRS autoantibodies in the plasma of normal subjects, and patients with type 1 DM, and patients with type 2 DM. Results: From the 65 (normal), 58 (type 1 DM) and 57 (type 2 DM) subjects, anti-aaRS autoantibodies were found in 37.9% of patients with type 1 DM compared with 1.54% of the non-diabetic controls, and 5.26% of the patients with type 2 DM (p <0.0001). In addition, anti-aaRS autoantibodies were identified in 30% of patients with type 1 DM without classical type 1 DM autoantibodies. Conclusion: Anti-aaRS autoantibodies were identified in 37.9% of patients with type 1 DM. The results of this study demonstrate for the first time that autoantibodies against aaRSs are specifically associated with type 1 DM.

KW - Antisynthetase syndrome

KW - Autoantibody

KW - Autoimmune disease

KW - ELISA

KW - Pancreas

UR - https://www.scopus.com/pages/publications/77952517565

U2 - 10.3109/13547501003777823

DO - 10.3109/13547501003777823

M3 - Article

C2 - 20429837

AN - SCOPUS:77952517565

SN - 1354-750X

VL - 15

SP - 358

EP - 366

JO - Biomarkers

JF - Biomarkers

IS - 4

ER -

Autoantibodies against aminoacyl-tRNA synthetase: Novel diagnostic marker for type 1 diabetes mellitus

Abstract

Bibliographical note

UN SDGs

Keywords

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