Abstract
Here, we disclose a new turn-on type fluorescent probe (named BCB-1) for the detection of Aβ plaques, which is an essential biomarker in Alzheimer's disease (AD). BCB-1 has a hybrid structure of benzo[g]coumarin and benzothiazole, and it showed significant emission enhancement at the near-infrared (NIR) region when sensing Aβ plaques. BCB-1 also showed high selectivity and sensitivity toward Aβ plaques, and its bio-imaging applicability was confirmed within an AD mouse (5XFAD) brain. We expect our superb AD diagnosis fluorescent probe to be broadly applied in Aβ plaques related clinical and biological studies.
| Original language | English |
|---|---|
| Pages (from-to) | 764-768 |
| Number of pages | 5 |
| Journal | Bulletin of the Korean Chemical Society |
| Volume | 43 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2022 |
Bibliographical note
Publisher Copyright:© 2022 Korean Chemical Society, Seoul & Wiley-VCH GmbH.
Keywords
- Alzheimer's disease
- amyloid plaque
- bioimaging
- biomarker
- molecular probe