Betulinic and oleanolic acids isolated from Forsythia suspensa Vahl inhibit urease activity of Helicobacter pylori

Seung Jung Shin; Chan El Park; Nam In Baek; In Sik Chung; Chang Ho Park

doi:10.1007/s12257-008-0272-4

Betulinic and oleanolic acids isolated from Forsythia suspensa Vahl inhibit urease activity of Helicobacter pylori

Seung Jung Shin, Chan El Park, Nam In Baek, In Sik Chung, Chang Ho Park

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Sixteen medicinal herbs were selected from a database on traditional herbal materials as well as literature on Korean plant resources. Then ethanol (70%, v/v) extracts of these herbs were tested for inhibition of the urease activity of Helicobacter pylori. The urease activity of H. pylori was strongly (82%) inhibited by extract of Forsythia suspensa Vahl. Active compounds in extract of Forsythia suspensa Vahl were first separated by batch mode solvent extraction, followed by purification by silica gel and octadecyl silica gel column chromatography using solvents of different polarity. According to NMR analysis of the last chromatographic fraction, we identified the presence of betulinic acid and oleanolic acid, which are known to have anti-inflammatory, anti-cancer, and anti-HIV viral activities.

Original language	English
Pages (from-to)	140-145
Number of pages	6
Journal	Biotechnology and Bioprocess Engineering
Volume	14
Issue number	2
DOIs	https://doi.org/10.1007/s12257-008-0272-4
Publication status	Published - 2009

Bibliographical note

Funding Information:
^ÅâåçïäÉÇÖãÉåí This research was supported by the Kyung Hee University Research Fund in 2004 (KHU-20040095).

Keywords

Extraction
Forsythia suspensa Vahl
Helicobacterpylori
NMR analysis
Urease activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12257-008-0272-4

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abstract = "Sixteen medicinal herbs were selected from a database on traditional herbal materials as well as literature on Korean plant resources. Then ethanol (70%, v/v) extracts of these herbs were tested for inhibition of the urease activity of Helicobacter pylori. The urease activity of H. pylori was strongly (82%) inhibited by extract of Forsythia suspensa Vahl. Active compounds in extract of Forsythia suspensa Vahl were first separated by batch mode solvent extraction, followed by purification by silica gel and octadecyl silica gel column chromatography using solvents of different polarity. According to NMR analysis of the last chromatographic fraction, we identified the presence of betulinic acid and oleanolic acid, which are known to have anti-inflammatory, anti-cancer, and anti-HIV viral activities.",

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AU - Park, Chan El

AU - Baek, Nam In

AU - Chung, In Sik

AU - Park, Chang Ho

N1 - Funding Information: ^ÅâåçïäÉÇÖãÉåí This research was supported by the Kyung Hee University Research Fund in 2004 (KHU-20040095).

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KW - Forsythia suspensa Vahl

KW - Helicobacterpylori

KW - NMR analysis

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Betulinic and oleanolic acids isolated from Forsythia suspensa Vahl inhibit urease activity of Helicobacter pylori

Abstract

Bibliographical note

Keywords

UN SDGs

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