Biocompatibility and mineralization potential of new calcium silicate cements

Byurira Kim, Yong Hyuk Lee, Ik Hwan Kim, Ko Eun Lee, Chung Min Kang, Hyo Seol Lee, Hyung Jun Choi, Kyounga Cheon, Je Seon Song, Yooseok Shin

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background/purpose: As calcium silicate cements (CSCs) have been successfully used in various types of vital pulp therapy, many new CSC products have been developed. The aim of this study was to evaluate the biocompatibilities and mineralization potential of new CSC. The experimental materials were NeoMTA Plus and EndoSequence Root Repair Material-Fast Set Putty (ERRM-FS) which were compared to ProRoot MTA. Materials and methods: In vitro, the effects of the new CSC on stem cells were evaluated. Each CSC was prepared for cell viability testing, alkaline phosphatase (ALP) assay, and calcium ion release assay. In vivo, the exposed pulp model was used for the partial pulpotomy procedure. Thirty-six teeth were treated with three materials: ProRoot MTA, NeoMTA Plus, or ERRM-FS. After four weeks, the teeth were extracted and processed for histologic analysis. Dentin bridge formation, pulp inflammation, and odontoblastic cell layer were evaluated and the area of newly formed calcific barrier of each group was measured. Results: Three CSCs demonstrated similar cell viability on stem cells and the levels of ALP and calcium release were not significantly different between tested materials. ProRoot MTA and ERRM-FS showed better tissue healing process than NeoMTA Plus after partial pulpotomy, in terms of quality of calcific barrier and pulp inflammation. The outcomes from measuring newly formed calcific area demonstrated no significant differences between the materials. Conclusion: NeoMTA Plus and ERRM-FS displayed similar biocompatibilities and mineralization potential compared to ProRoot MTA. Therefore, these new CSCs can be used as desirable alternatives to ProRoot MTA.

Original languageEnglish
Pages (from-to)1189-1198
Number of pages10
JournalJournal of Dental Sciences
Volume18
Issue number3
DOIs
Publication statusPublished - Jul 2023

Bibliographical note

Publisher Copyright:
© 2022 Association for Dental Sciences of the Republic of China

Keywords

  • Biocompatibility
  • Calcium silicate cement
  • Mineralization potential
  • Partial pulpotomy

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