Bioinspired layered nanoclays for nutraceutical delivery system

This review focused on the promising potential of nanoclays as nutraceutical delivery systems. In nature, two forms of nanoclays, anionic and cationic clays, are present depending on the surface layered charge and the types of interlayer ions. Nanoclays including anionic and cationic clays have unique layered structure which enables intercalation of nutraceuticals and bioactive agents into the gallery spaces without any changes in their chemical and functional properties. They also have efficient cell permeation, high mucoadhesive, and low toxic properties that offer a new route to enhance the bioavailability of bioactive agents through oral administration. The preparation, physical/chemical characterization and bioavailability of nanoclay based delivery systems as well as their applications in food system as a nanocarrier for vitamins, antioxidants, linoleic acid, and other neutraceuticals are discussed.