Biotin-guided anticancer drug delivery with acidity-triggered drug release

Soyeon Park; Eunjin Kim; Won Young Kim; Chulhun Kang; Jong Seung Kim

doi:10.1039/c5cc03003j

Biotin-guided anticancer drug delivery with acidity-triggered drug release

Soyeon Park
, Eunjin Kim
, Won Young Kim
, Chulhun Kang
, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.

Original language	English
Pages (from-to)	9343-9345
Number of pages	3
Journal	Chemical Communications
Volume	51
Issue number	45
DOIs	https://doi.org/10.1039/c5cc03003j
Publication status	Published - 7 Jun 2015

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2015.

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10.1039/c5cc03003j

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title = "Biotin-guided anticancer drug delivery with acidity-triggered drug release",

abstract = "A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.",

author = "Soyeon Park and Eunjin Kim and Kim, \{Won Young\} and Chulhun Kang and Kim, \{Jong Seung\}",

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year = "2015",

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doi = "10.1039/c5cc03003j",

language = "English",

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AU - Park, Soyeon

AU - Kim, Eunjin

AU - Kim, Won Young

AU - Kang, Chulhun

AU - Kim, Jong Seung

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015/6/7

Y1 - 2015/6/7

N2 - A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.

AB - A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.

UR - https://www.scopus.com/pages/publications/84930211772

U2 - 10.1039/c5cc03003j

DO - 10.1039/c5cc03003j

M3 - Article

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AN - SCOPUS:84930211772

SN - 1359-7345

VL - 51

SP - 9343

EP - 9345

JO - Chemical Communications

JF - Chemical Communications

IS - 45

ER -

Biotin-guided anticancer drug delivery with acidity-triggered drug release

Abstract

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