BRCA and Breast Cancer-Related High-Penetrance Genes

Sang Ah Han; Sung Won Kim

doi:10.1007/978-981-32-9620-6_25

BRCA and Breast Cancer-Related High-Penetrance Genes

Sang Ah Han
, Sung Won Kim

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

19 Citations (Scopus)

Abstract

Genetic susceptibility explains 5–10% of all breast cancer cases. High-penetrance breast cancer susceptibility genes deliberate a greater than tenfold relative risk of breast cancer. BRCA1 and BRCA2 genes are the most common cause of hereditary breast cancer, and TP53, PTEN, and SKT11 (LKB1) are rarely present. The prevalence of BRCA1 and BRCA2 genetic alterations differ in various ethnic groups. The Korean Hereditary Breast Cancer (KOHBRA) Study, nationwide-scale study, was established to acquire evidence for the accurate risk assessment and management of hereditary breast and ovarian cancer (HBOC) in Korea prospectively since 2007. In this chapter, we review previous research related to hereditary breast cancer and summarize the present concepts and research results centered on the Korean Hereditary Breast Cancer Research at this time.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer
Pages	473-490
Number of pages	18
DOIs	https://doi.org/10.1007/978-981-32-9620-6_25
Publication status	Published - 2021

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1187
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Bibliographical note

Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2021.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BRCA1/2
Breast cancer
Genetic susceptibility
KOHBRA study
PTEN
STK11
TP53

Access to Document

10.1007/978-981-32-9620-6_25

Cite this

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title = "BRCA and Breast Cancer-Related High-Penetrance Genes",

abstract = "Genetic susceptibility explains 5–10\% of all breast cancer cases. High-penetrance breast cancer susceptibility genes deliberate a greater than tenfold relative risk of breast cancer. BRCA1 and BRCA2 genes are the most common cause of hereditary breast cancer, and TP53, PTEN, and SKT11 (LKB1) are rarely present. The prevalence of BRCA1 and BRCA2 genetic alterations differ in various ethnic groups. The Korean Hereditary Breast Cancer (KOHBRA) Study, nationwide-scale study, was established to acquire evidence for the accurate risk assessment and management of hereditary breast and ovarian cancer (HBOC) in Korea prospectively since 2007. In this chapter, we review previous research related to hereditary breast cancer and summarize the present concepts and research results centered on the Korean Hereditary Breast Cancer Research at this time.",

keywords = "BRCA1/2, Breast cancer, Genetic susceptibility, KOHBRA study, PTEN, STK11, TP53",

author = "Han, \{Sang Ah\} and Kim, \{Sung Won\}",

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year = "2021",

doi = "10.1007/978-981-32-9620-6\_25",

language = "English",

series = "Advances in Experimental Medicine and Biology",

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T1 - BRCA and Breast Cancer-Related High-Penetrance Genes

AU - Han, Sang Ah

AU - Kim, Sung Won

N1 - Publisher Copyright: © Springer Nature Singapore Pte Ltd. 2021.

PY - 2021

Y1 - 2021

N2 - Genetic susceptibility explains 5–10% of all breast cancer cases. High-penetrance breast cancer susceptibility genes deliberate a greater than tenfold relative risk of breast cancer. BRCA1 and BRCA2 genes are the most common cause of hereditary breast cancer, and TP53, PTEN, and SKT11 (LKB1) are rarely present. The prevalence of BRCA1 and BRCA2 genetic alterations differ in various ethnic groups. The Korean Hereditary Breast Cancer (KOHBRA) Study, nationwide-scale study, was established to acquire evidence for the accurate risk assessment and management of hereditary breast and ovarian cancer (HBOC) in Korea prospectively since 2007. In this chapter, we review previous research related to hereditary breast cancer and summarize the present concepts and research results centered on the Korean Hereditary Breast Cancer Research at this time.

AB - Genetic susceptibility explains 5–10% of all breast cancer cases. High-penetrance breast cancer susceptibility genes deliberate a greater than tenfold relative risk of breast cancer. BRCA1 and BRCA2 genes are the most common cause of hereditary breast cancer, and TP53, PTEN, and SKT11 (LKB1) are rarely present. The prevalence of BRCA1 and BRCA2 genetic alterations differ in various ethnic groups. The Korean Hereditary Breast Cancer (KOHBRA) Study, nationwide-scale study, was established to acquire evidence for the accurate risk assessment and management of hereditary breast and ovarian cancer (HBOC) in Korea prospectively since 2007. In this chapter, we review previous research related to hereditary breast cancer and summarize the present concepts and research results centered on the Korean Hereditary Breast Cancer Research at this time.

KW - BRCA1/2

KW - Breast cancer

KW - Genetic susceptibility

KW - KOHBRA study

KW - PTEN

KW - STK11

KW - TP53

UR - https://www.scopus.com/pages/publications/85105840352

U2 - 10.1007/978-981-32-9620-6_25

DO - 10.1007/978-981-32-9620-6_25

M3 - Chapter

C2 - 33983595

AN - SCOPUS:85105840352

T3 - Advances in Experimental Medicine and Biology

SP - 473

EP - 490

BT - Advances in Experimental Medicine and Biology

PB - Springer

ER -

BRCA and Breast Cancer-Related High-Penetrance Genes

Abstract

Publication series

Bibliographical note

UN SDGs

Keywords

Access to Document

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