Calcium carbonate-mineralized polymer nanoparticles for pH-responsive robust nanocarriers of docetaxel

Byung Joo Kim; Kyung Hyun Min; Gyu Ha Hwang; Hong Jae Lee; Seo Young Jeong; Eun Cheol Kim; Sang Cheon Lee

doi:10.1007/s13233-015-3020-6

Calcium carbonate-mineralized polymer nanoparticles for pH-responsive robust nanocarriers of docetaxel

Byung Joo Kim, Kyung Hyun Min, Gyu Ha Hwang, Hong Jae Lee, Seo Young Jeong, Eun Cheol Kim, Sang Cheon Lee

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A calcium carbonate (CaCO₃)-mineralized core-shell-corona micelle was evaluated as an intracellular nanocarrier of docetaxel (DTX). The polymer micelle consisting of the poly(ethylene glycol) coronal, the anionic poly(L-aspartic acid) middle shell, and the DTX-loaded hydrophobic poly(L-phenylalanine) core was used as a nanotemplate for CaCO₃ mineralization was performed by initial electrostatic localization of calcium ions at the anionic PAsp middle shells, and the subsequent addition of carbonate anions to trigger the growth of CaCO₃ around the PAsp middle shells. Even after mineralization, the micelle size and the spherical morphology were maintained. The CaCO₃-mineralized micelles exhibited enhanced stability against micelle-disrupting surfactants and the serums. The mineralized CaCO₃ layer could suppress DTX release efficiently at extracellular pH (7.4) but dissolve at an intracellular endosomal pH (pH ~ 5.0) to facilitate the DTX release. These results reveal the promising potential of CaCO₃-mineralized polymer micelle as a stable and effective nanocarrier system in tumor therapy.

Original language	English
Pages (from-to)	111-117
Number of pages	7
Journal	Macromolecular Research
Volume	23
Issue number	1
DOIs	https://doi.org/10.1007/s13233-015-3020-6
Publication status	Published - Jan 2015

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Publisher Copyright:
© 2015, The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht.

Keywords

calcium carbonate
docetaxel
intracellular release
mineralization
pH-responsive

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10.1007/s13233-015-3020-6

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title = "Calcium carbonate-mineralized polymer nanoparticles for pH-responsive robust nanocarriers of docetaxel",

abstract = "A calcium carbonate (CaCO3)-mineralized core-shell-corona micelle was evaluated as an intracellular nanocarrier of docetaxel (DTX). The polymer micelle consisting of the poly(ethylene glycol) coronal, the anionic poly(L-aspartic acid) middle shell, and the DTX-loaded hydrophobic poly(L-phenylalanine) core was used as a nanotemplate for CaCO3 mineralization was performed by initial electrostatic localization of calcium ions at the anionic PAsp middle shells, and the subsequent addition of carbonate anions to trigger the growth of CaCO3 around the PAsp middle shells. Even after mineralization, the micelle size and the spherical morphology were maintained. The CaCO3-mineralized micelles exhibited enhanced stability against micelle-disrupting surfactants and the serums. The mineralized CaCO3 layer could suppress DTX release efficiently at extracellular pH (7.4) but dissolve at an intracellular endosomal pH (pH ~ 5.0) to facilitate the DTX release. These results reveal the promising potential of CaCO3-mineralized polymer micelle as a stable and effective nanocarrier system in tumor therapy.",

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author = "Kim, {Byung Joo} and Min, {Kyung Hyun} and Hwang, {Gyu Ha} and Lee, {Hong Jae} and Jeong, {Seo Young} and Kim, {Eun Cheol} and Lee, {Sang Cheon}",

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AU - Hwang, Gyu Ha

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AU - Jeong, Seo Young

AU - Kim, Eun Cheol

AU - Lee, Sang Cheon

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N2 - A calcium carbonate (CaCO3)-mineralized core-shell-corona micelle was evaluated as an intracellular nanocarrier of docetaxel (DTX). The polymer micelle consisting of the poly(ethylene glycol) coronal, the anionic poly(L-aspartic acid) middle shell, and the DTX-loaded hydrophobic poly(L-phenylalanine) core was used as a nanotemplate for CaCO3 mineralization was performed by initial electrostatic localization of calcium ions at the anionic PAsp middle shells, and the subsequent addition of carbonate anions to trigger the growth of CaCO3 around the PAsp middle shells. Even after mineralization, the micelle size and the spherical morphology were maintained. The CaCO3-mineralized micelles exhibited enhanced stability against micelle-disrupting surfactants and the serums. The mineralized CaCO3 layer could suppress DTX release efficiently at extracellular pH (7.4) but dissolve at an intracellular endosomal pH (pH ~ 5.0) to facilitate the DTX release. These results reveal the promising potential of CaCO3-mineralized polymer micelle as a stable and effective nanocarrier system in tumor therapy.

AB - A calcium carbonate (CaCO3)-mineralized core-shell-corona micelle was evaluated as an intracellular nanocarrier of docetaxel (DTX). The polymer micelle consisting of the poly(ethylene glycol) coronal, the anionic poly(L-aspartic acid) middle shell, and the DTX-loaded hydrophobic poly(L-phenylalanine) core was used as a nanotemplate for CaCO3 mineralization was performed by initial electrostatic localization of calcium ions at the anionic PAsp middle shells, and the subsequent addition of carbonate anions to trigger the growth of CaCO3 around the PAsp middle shells. Even after mineralization, the micelle size and the spherical morphology were maintained. The CaCO3-mineralized micelles exhibited enhanced stability against micelle-disrupting surfactants and the serums. The mineralized CaCO3 layer could suppress DTX release efficiently at extracellular pH (7.4) but dissolve at an intracellular endosomal pH (pH ~ 5.0) to facilitate the DTX release. These results reveal the promising potential of CaCO3-mineralized polymer micelle as a stable and effective nanocarrier system in tumor therapy.

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Calcium carbonate-mineralized polymer nanoparticles for pH-responsive robust nanocarriers of docetaxel

Abstract

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